Research

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Minor early changes in lungs can signal changes in progressive lung disease

The research focused on the very early stages of FPF, a serious progressive lung disease where for unknown reasons scar tissue builds up in the lungs over time.

Co-principal investigators of the genomic-enabled learning health system coordinating center and clinical site are, front row from left, Carolyn Audet, PhD, Alexander Bick, MD, PhD, and Sunil Kripalani, MD, MSc, and, back row from left, Wesley Self, MD, MPH, Josh Peterson, MD, MPH, and Dan Roden, MD. (photo by Susan Urmy)

‘Learning’ network will help move genomics into the clinic

A real-world learning health system was established at VUMC a decade ago. Now, the National Human Genome Research Institute is awarding two five-year grants totaling $12 million to support VUMC’s participation in, and coordination of, a genomic-enabled learning health system (gLHS) network.

Image of the U.S., with markers that note cities where the Home Owners’ Loan Corp. conducted a city survey of impacted areas. (Source: Mapping Inequality)

Poverty rates linked to asthma in ‘redlined’ areas

Neighborhoods that were discriminated against, called ‘redlined areas,’ are known to have higher levels of air pollution from industry and vehicles, especially diesel-fueled trucks, buses and cars.

Douglas Terry, PhD. (photo by Donn Jones)

New study reveals common belief of CTE, link to mental health among former professional NFL players

“Understanding the proportion of former players who think they have CTE — and identifying the common symptoms in those who believe they have CTE — is an important step for helping these individuals receive medical and mental health treatment,” said Douglas Terry, PhD, assistant professor and clinical neuropsychologist in the Department of Neurological Surgery and co-director of the Vanderbilt Sports Concussion Center.

VUMC method tracks down rare, broadly reacting antibodies: study

The discovery, reported in the journal PLOS Pathogens, could help open the door to the development of effective vaccines and antibody therapies with an “exceptional breadth of pathogen coverage.”

Fever drives enhanced activity, mitochondrial damage in immune cells

The mechanistic understanding of how cells respond to heat could explain how chronic inflammation contributes to the development of cancer.

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