An enzyme therapy may prevent skeletal abnormalities associated with the genetic disorder neurofibromatosis type-1, Vanderbilt investigators have discovered.

Researchers at Vanderbilt University, the University of Arizona and Phoenix Children’s Hospital have discovered what triggers a rare but devastating diarrheal disease in newborns that is fatal without intravenous feeding or intestinal transplant.

A Vanderbilt University-led research team has identified protein “signatures” of genetic mutations that drive colorectal cancer, the nation’s second leading cause of cancer deaths after lung cancer.

A newly identified receptor allows mammalian reovirus to infect neurons, shedding light on factors important for viral encephalitis.

A protein essential for growth of normal breast tissue also may play a role in breast cancer, Vanderbilt University researchers have found.

Engineered bacteria that produce a therapeutic compound in the gut prevent obesity in mice, Vanderbilt University investigators have discovered.

A novel molecular “conversation” regulates kidney fibrosis – the final result of end-stage chronic kidney disease – suggesting new treatment options for this currently irreversible process.