Leigh MacMillan

Disease linked to cell traffic jams

Diseases associated with mutations and changes in expression of the protein caveolin may result from faulty trafficking of the protein to the cell surface.

Antacids: risky for premature babies

Antacids that block a certain enzyme pose a risk for a common cardiac problem in premature infants.

Factor’s yin-yang tumor effects

A factor produced by most malignant cells can both promote and inhibit tumor growth – an insight that is critical to using cancer drugs developed to block this factor.

Study tracks skin salt’s role in blood pressure control

Clinical pharmacologist Jens Titze, M.D., and his colleagues have identified a new cast of cells and molecules that function in the skin to control sodium balance and blood pressure.

Insulin in vials

Matrix member key to insulin resistance

A component of the extracellular matrix that surrounds cells plays a role in insulin resistance and may be a good therapeutic target.

Study lays groundwork for rational T cell vaccine design

Vanderbilt University investigators have developed a new strategy for identifying the “bits” of a pathogen that spark a protective immune response.

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