Leigh MacMillan

The nuclear receptor TR3 contributes to ovarian cancer cell death in response to platinum-based chemotherapy – and may be a good target for overcoming cell resistance to certain treatments.

In an effort to understand how neurons develop different “architectures,” Vanderbilt developmental biologists have discovered a genetic switch that controls one type of neuron branching in the nematode worm.

A noninvasive test can be used to identify the presence of Helicobacter pylori and evaluate its virulence, which will be useful in areas with high rates of H. pylori-associated gastric cancer.

Gaining and losing weight during “yo-yo dieting” may contribute to an exaggerated immune response in fat tissue that increases metabolic dysfunction more than steady weight gain alone.

Insight into how the protein neurofibromin participates in the signaling pathway that produces the body’s long bones has implications for fracture healing in some patients.

A motor protein that helps drive cell division may be a promising new target for cancer therapeutics.