Leigh MacMillan

Gene regulation found to play role in pulmonary hypertension

New findings from Vanderbilt researchers may explain why only some individuals who have inherited mutations that increase risk for pulmonary hypertension actually develop the disease.

Setting traps to probe gene function

A new method for creating genetic mutations that can be activated at certain times or in specific tissues will enable studies to probe gene function.

Amish aid search for Alzheimer’s genes

An analysis of Amish populations revealed novel risk genes for late-onset Alzheimer disease.

Host proteins can control HIV infection

The protein APOBEC3G contributes to spontaneous control of HIV-1 in vivo and may provide therapeutic benefits.

Proteins help flip tumor’s invasive switch

Vanderbilt investigators have identified how two key components of cancer’s invasive “switch” — the series of signaling events that turn on a tumor cell’s invasive behavior — work together.

Cell entry ports for cold virus

The respiratory virus HMPV uses its fusion (F) protein – which interacts with cellular receptors called integrins – to bind to and enter target cells.

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