Aliquots - Research Briefs

October 2, 2015

The yin and yang of COX-2

New findings add to the understanding of how the enzyme COX-2 works, which is critical to the development of COX-2-targeted anti-inflammatory drugs.

By Sanjay Mishra
conceptual - glowing cell
October 1, 2015

Tolerating a transplant

A new genetic model has generated new strategies for promoting tolerance to transplants – and improving long-term transplant outcomes – in the background of autoimmune disease.

By Leigh MacMillan
September 23, 2015

Data diving for health

To most effectively use electronic health records for research, investigators should query multiple components of the record to identify patients with specific diseases.

By VUMC News and Communications
September 22, 2015

Keep your coat on, virus!

A compound acting on serotonin receptors delays a critical step during reovirus cell entry, reducing viral infectivity.

By Sanjay Mishra
September 18, 2015

Nerve cell remodelers

Vanderbilt investigators have defined a gene expression program that controls the timing of synaptic remodeling – a process that is critical to brain development, learning and memory.

By Leigh MacMillan
September 17, 2015

Heart repair factor

A signaling factor called Wnt10b is a novel target for optimizing cardiac repair after a heart attack.

By Yan Su
September 9, 2015

How to build a basement

Understanding the action of a certain enzyme will shed light on basement membrane function, and on disorders ranging from diabetic kidney disease to cancer.
By Sanjay Mishra
September 8, 2015

Immune cells and obesity

Understanding how macrophage immune cells accumulate in fat tissue and contribute to the pathology of obesity could lead to the development of novel therapeutics for metabolic disorders.
By Leigh MacMillan
September 4, 2015

Vitamin C protects blood vessel lining

Dietary vitamin C may maintain healthy blood vessels in patients with inflammatory diseases.
By Leigh MacMillan
September 3, 2015

Bad “traffic” linked to cancer

Understanding how signaling molecules are transported within and out of the cell may help to uncover the causes of certain cancers.
By VUMC News and Communications
August 26, 2015

Framework for studying cell responses

Vanderbilt investigators have developed a framework for studying cellular responses that could be used to identify the agents driving a range of biological processes in health and disease.
By Leigh MacMillan
August 25, 2015

How the cell makes morphine

Vanderbilt investigators have discovered how mammals, including humans, produce the painkiller morphine.
By Sanjay Mishra
August 21, 2015

Brain circuitry in psychosis

Functional magnetic resonance imaging has revealed faulty circuits between the thalamus – a central hub of brain activity – and other brain regions.
By Leigh MacMillan