Research

March 11, 2024

Phase 3 CELLEBRATE trial testing regenerative stem cell-based therapy to improve urinary control for women

The Phase 3 CELLEBRATE trial to test a regenerative stem cell-based therapy in treating patients with stress urinary incontinence is continuing to recruit additional subjects after changing its study protocol to include only patients who have already tried surgery. 

By Craig Boerner
March 7, 2024

Study details metabolism of biomarkers for oxidative stress

Factors other than oxidative stress can modify the levels of biomarkers called isoprostanes that are commonly used in both experimental and clinical research, suggesting that additional standards need to be developed.

By Leigh MacMillan
March 7, 2024

Blood mutations increase risk for acute kidney injury: study

A U.S.-Canadian research collaboration led by Vanderbilt University Medical Center has identified common, age-associated changes in the blood as a risk factor for acute kidney injury, which occurs in more than 1 in 5 hospitalized adults worldwide.

By Bill Snyder
March 4, 2024

Dame Frances Ashcroft to deliver March 21 Vanderbilt Prize Lecture

Professor Dame Frances Ashcroft, recipient of the 2023 Vanderbilt Prize in Biomedical Science, will deliver her Vanderbilt Prize Discovery Lecture at 4 p.m. Thursday, March 21, in 208 Light Hall.

By Bill Snyder
February 27, 2024

Multi-institutional study of Wilms tumor facilitates enrollment, optimizes treatment

Multi-institutional study finds that enrollment and outcomes were similar across racial and ethnic groups for children participating in therapeutic trials for Wilms tumor — the most common pediatric kidney cancer worldwide.

By Leigh MacMillan
February 21, 2024

Large, diverse genetic study of glaucoma implicates vascular and cancer-related genes

An international genetic study using multiancestry biobanks has identified novel genetic locations associated with primary open-angle glaucoma, the most common type of glaucoma and the leading cause of irreversible blindness globally.

By Leigh MacMillan
February 19, 2024

VUMC part of major step to achieving precision medicine

An analysis of genomic data from nearly 250,000 participants in the National Institutes of Health’s All of Us Research Program has identified more than 275 million previously unreported genetic variations, nearly 4 million of which have potential health consequences.
By Bill Snyder
February 12, 2024

VISTA grant to fund hospital-based research training in heart, lung, blood, sleep disorders

Vanderbilt University Medical Center has received a federal grant to establish a first-of-its-kind training program in patient-oriented and health systems research focused on acute heart, lung, blood and sleep disorders in the hospital setting.
By Bill Snyder
February 7, 2024

Vanderbilt nanodrug may be a paradigm shift for cancer

A multidisciplinary research team at Vanderbilt University and Vanderbilt University Medical Center has discovered a new way to kill a tumor by disrupting its acidic “microenvironment” without harming normal tissue.
By Bill Snyder
February 7, 2024

VUMC study finds molecular switch key to repair of kidney damage

Researchers at Vanderbilt University Medical Center have identified Rac1, a molecular switch that regulates the actin cytoskeleton of epithelial cells in the collecting ducts, as a driver of post-obstructive kidney repair.
By Bill Snyder
February 1, 2024

A biomarker for early Type 2 diabetes

Genetic analyses suggest that branched chain amino acids may be a sensitive biomarker of early or subclinical Type 2 diabetes and could be used to identify risk and implement preventive measures.
By Bill Snyder
January 31, 2024

Fatty acids rewire energy supply chain in stomach cancer development

A study by Vanderbilt researchers has revealed how metabolic changes spurred by fatty acids contribute to the transformation of cells into abnormal versions of themselves that are the precursors to stomach cancer.
By Tom Wilemon
January 30, 2024

3D brain mapping opens a window to the aging brain

By mapping brain activity in three dimensions, researchers at Vanderbilt University Medical Center have achieved a more detailed picture of how the brain changes with age.
By Bill Snyder
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