Aliquots

An image of cancer treatment response

An MRI method developed by Vanderbilt researchers uses imaging data to derive cell size and could be added to clinical practice for better monitoring of breast cancer treatment response.

Treating kidney injury before it happens

Pretreatment of an animal model with a novel compound called PHAD reduced kidney injury, suggesting it may be a good candidate for preventing kidney injury in surgical patients.

Neurofluid flow and Alzheimer’s disease

Vanderbilt researchers used novel MRI methods to noninvasively quantify measures of neurofluid circulation and found that hypertrophy of a site of cerebrospinal fluid egress may be related to amyloid-beta retention in Alzheimer’s disease.

skin cross section

A critical skin enzyme

Detailed studies of the enzymatic properties of PNPLA1 support the requirement for this protein in skin barrier formation.

Billing codes aid lupus diagnosis

Vanderbilt researchers used billing codes in electronic health records to develop a “phenotype risk score” that identified established and undiagnosed people with lupus.

Neural networks probe proteins

A machine learning method based on neural networks outperformed a mutational scanning model at identifying disease-causing mutations in an Alzheimer’s disease protein, suggesting the method could be useful for facilitating therapeutic design.

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