Aliquots

May 23, 2014

Repair protein’s DNA recognition motif

Insights into the workings of DNA damage response proteins such as SMARCAL1 could suggest new ways to improve genome integrity and prevent cancer.

By Leigh MacMillan
May 22, 2014

Cellular forces aid tumor invasion

The contractile machinery inside tumor cells increases invasive properties, suggesting it might be a good target to inhibit cancer cell spread.

By VUMC News and Communications
Insulin in vials
May 14, 2014

CaMKII enhances insulin secretion

The protein CaMKII acts as a calcium sensor in a positive feedback pathway that enhances glucose-stimulated insulin secretion.

By VUMC News and Communications
Heart illustration thumbnail
May 12, 2014

Normalizing calcium flux to treat atrial fibrillation

A particular anti-arrhythmia drug provides a targeted treatment for certain forms of atrial fibrillation.

By Leigh MacMillan
May 9, 2014

Bypassing DNA damage

Studies of a human polymerase that replicates DNA have provided a complete kinetic and structural framework for understanding how the enzyme accurately bypasses DNA damage.

By VUMC News and Communications
May 8, 2014

PET probe detects dying tumor cells

A novel PET imaging probe detects tumor cell death in vivo and could be useful for personalizing cancer medicine.

By Leigh MacMillan
April 30, 2014

Potential mechanism for myeloma drug’s variable toxicity

A genetic variant is associated with toxicity of the chemotherapy drug melphalan, and could guide individualized dosing for the medication.
By Leigh MacMillan
April 28, 2014

Target cell entry to halt Chikungunya virus

Understanding how chikungunya virus binds to and enters cells offers a new target for antiviral medications.
By Leigh MacMillan
April 25, 2014

Increased cell permeability may protect from colitis

Having a “leaky” gut may protect against colitis, a paradoxical finding that alters understanding of the role of cell permeability in intestinal homeostasis and immune regulation.
By Leigh MacMillan
April 24, 2014

New view of neurotransmitter transport

Dynamic measurements of the bacterial leucine transporter shed light on the transporters that play roles in neuropsychiatric and addiction disorders.
By Leigh MacMillan
April 16, 2014

Channel drug restores glucose balance

A new compound that activates potassium channels could be used to treat disorders of glucose homeostasis.
By Bill Snyder
April 15, 2014

Anthrax bacteria’s signaling systems

Vanderbilt researchers have identified a new signaling system that anthrax bacteria uses to infect its host.
By Leigh MacMillan
April 11, 2014

Myelin junctions key to conduction

A protein in the myelin coating on nerves helps form a “seal” that enables effective nerve conduction; loss of the protein causes inherited neuropathies.
By Leigh MacMillan
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