Basic Sciences

Vanderbilt investigators have found that aging induces chronic cellular stress in pancreatic beta cells, which could contribute to the development of diabetes as we age.

Vanderbilt researchers are elucidating the neuronal pathways that contribute to food consumption in response to stress — “comfort feeding” — and how they differ in males versus females and in the context of obesity.

Vanderbilt researchers have discovered details of pancreatic beta cell loss — and potential therapeutic targets — during conditions of overnutrition, as occurs in obesity.

An ingenious targeted nanoparticle approach developed by Vanderbilt researchers reduced tumor burden in a model of ovarian cancer.

Vanderbilt researchers used single-cell sequencing, imaging, and computational approaches to characterize the colonic tumor microenvironment, providing important insights to the components that play roles in colorectal tumor pathogenesis.

Vanderbilt has named John Kuriyan, PhD, one of the world’s leading structural biologists, as its next dean of the School of Medicine Basic Sciences.