cancer biology

Research by Ann Richmond, PhD, second from left, Chi Yan, PhD, left, Kensey Bergdorf, PhD, JinMing Yang, PhD, and colleagues is leading to new insights on melanoma tumor formation and growth.
June 29, 2023

Study identifies key regulator of melanoma development

Vanderbilt investigators have revealed the mechanisms by which the chemokine receptor CXCR2, is associated with melanoma tumor formation and growth — a discovery that supports the continued development of drugs that inhibit the receptor’s activity.

By Tom Wilemon
November 11, 2022

Study finds inherited link to appendix cancer

A Vanderbilt study is the first to show inherited risk factors for appendiceal cancer.

By Tom Wilemon
August 16, 2022

Nanoparticles boost anti-cancer immunity

An ingenious targeted nanoparticle approach developed by Vanderbilt researchers reduced tumor burden in a model of ovarian cancer.

By Bill Snyder
August 11, 2022

Cell-free breast cancer “biopsy”

The circulating DNA that tumors release is a reliable metric of tumor genomics and can be used to monitor molecular changes in metastatic breast cancer.

By Sarah E. Glass
July 15, 2022

Holowatyj named chair of scientific advisory board for ACPMP Research Foundation

Vanderbilt’s Andreana Holowatyj, PhD, MSCI, has been named the inaugural chair of the scientific advisory board for the Appendix Cancer Pseudomyxoma Peritonei Research Foundation.

By Tom Wilemon
May 6, 2021

IMPACT research grants to help underserved patients access clinical trials

The Leukemia & Lymphoma Society (LLS) announced today the launch of IMPACT (Influential Medicine Providing Access to Clinical Trials) research grants to increase enrollment of individuals from underrepresented communities in clinical trials. Vanderbilt University Medical Center is leading one of the first three projects to receive IMPACT funding.

By VUMC News and Communications
December 17, 2020

Study reveals distinct genomic landscape for young adults with appendiceal cancer

The first study to compare molecular landscapes of early-onset and late-onset appendiceal cancer has revealed distinct non-silent mutations in the tumors of younger patients, setting the stage for the development of potential therapeutic advances for this rare disease.
By Tom Wilemon
August 1, 2019

Grant bolsters research on myelodysplastic syndromes

Michael Savona, MD, has received a competitive grant to develop therapies for patients with myelodysplastic syndromes.
By Tom Wilemon
February 28, 2019

Protein loss promotes cell migration

The protein kinase STK17A plays a novel role in epithelial cells and its loss may contribute to colorectal cancer invasion and metastasis, Vanderbilt researchers report.
By Leigh MacMillan
December 13, 2018

Breast cancer-killing RIG

A compound that activates a virus-sensing receptor has potent therapeutic effects in a mouse model of breast cancer.
By Leigh MacMillan
April 11, 2018

“Idling” cancer cells may return

Vanderbilt investigators have discovered that cancer treatment induces an “idling” state for cells, which could promote resistance to treatment.
By Bill Snyder
November 15, 2017

Radiation and pulmonary fibrosis

To develop strategies for preventing radiation-induced lung fibrosis (scarring), Vanderbilt investigators are exploring the cell types and factors that contribute to the fibrotic response.
By Leigh MacMillan
October 4, 2017

Boosting sarcoma cell death

A compound identified at Vanderbilt represents a new lead for treating rare, aggressive childhood cancers called Ewing sarcomas.
By Leigh MacMillan
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