Center in Molecular Toxicology

Copper toxicity and Parkinson’s

A genetic predisposition to Parkinson’s disease makes neurons more vulnerable to the toxicity of heavy metals such as copper.

Bypassing DNA damage

Studies of a human polymerase that replicates DNA have provided a complete kinetic and structural framework for understanding how the enzyme accurately bypasses DNA damage.

DNA sequence

VU ‘crosslinks’ study sheds light on chemical toxicity

Vanderbilt researchers have characterized the chemical structures of a series of DNA-protein “crosslinks” that may lead to better ways to avoid the cancer-causing potential of environmental chemicals and prevent some drug toxicities.

Toxicology society honors Guengerich

F. Peter (Fred) Guengerich, Ph.D., Stanford Moore Professor of Biochemistry, is the 2013 recipient of the Society of Toxicology Merit Award in recognition of distinguished achievements to toxicology throughout his career.

Carcinogenic chemicals cramp DNA

Researchers have determined how a DNA lesion caused by exposure to chemicals may spark cancer formation.

DNA: From modification to mutation

Understanding how an environmental hazard damages DNA may shed light on processes of tumor formation.