Charles Sanders

July 3, 2023

Vanderbilt investigators land Keck Foundation grant for groundbreaking genetic research

Vanderbilt scientists have received a $1.2 million award from the W. M. Keck Foundation for their groundbreaking project, “Genetic Intolerance Patterns as a Treasure Map to Genes that Define Us as Human.”

March 30, 2023

Discussing cryo-EM

Yifan Chang, PhD, recently spoke about his team’s research using single particle cryo-EM (cryogenic electron microscopy) to study INO80, an ATP-dependent chromatin remodeling complex.

April 15, 2021

Arrhythmia culprit: supertrafficking ion channel

Charles Sanders, PhD, and colleagues show how a “supertrafficking” mutant potassium channel contributes to heart rhythm abnormalities.

ekg results
March 12, 2018

Long QT syndrome – revealed

Vanderbilt investigators have used sophisticated cell biological and structural techniques to “classify” mutations in potassium channels, studies that could lead to personalized treatment of heart rhythm disorders.

colored representation of cells and glia
August 17, 2017

Discovery sheds light on protein key to nerve cells’ myelin sheath

Genetic mutations in PMP22 (peripheral myelin protein 22) cause a variety of peripheral neuropathies, underscoring the importance of the protein to a healthy peripheral nervous system. But the precise function of PMP22, a major component of the myelin sheath that surrounds and insulates peripheral nerve cell axons, has been unclear.

elderly Asian mother and adult daughter
April 27, 2017

Protein structure may aid in treating Alzheimer’s disease

A new protein structure may guide the development of Alzheimer’s therapeutics.