Clinical Pharmacology & Therapeutics Archive — Page 1 of 1

Conceptual 3D illustration of red, spiked SARS-CoV-2 particles surrounded by Y-shaped ACE2 receptors on a glowing orange background.
August 12, 2021

Certain drug exposures correlate with reduced COVID severity: study

Analyzing electronic health records (EHR) of 9,748 patients diagnosed with COVID-19, Cosmin Bejan, PhD, Elizabeth Phillips, MD, and colleagues at Vanderbilt University Medical Center asked whether COVID disease severity correlated with any drugs that happened to be taken by these patients in the months leading up to their diagnosis.

By Paul Govern
Manual blood pressure monitor with a blue cuff, round pressure gauge, black inflation bulb, and attached stethoscope on a white background.
March 28, 2019

Drug interaction causes hypotension

A muscle relaxing-drug and inhibitors of the metabolic enzyme CYP1A2 interact to cause severely low blood pressure and should not be co-prescribed, Vanderbilt investigators caution.

By Leigh MacMillan
Doctor in a white coat holding a colorful DNA double-helix model, with a stethoscope around the neck.
March 31, 2016

Study looks at doctors’ response to genetic testing

A new clinical implementation study from Vanderbilt University Medical Center measures how physicians have responded to the introduction of routine genetic testing to predict patient response to the commonly prescribed antiplatelet drug clopidogrel.

By Paul Govern
Tablet displaying green and red electrocardiogram waveforms beside a medical form with sections titled “PRESENT ILLNESS” and “DIAGNOSTIC TESTS.”
March 31, 2014

E-records shed light on drug response

Electronic medical records linked to DNA biobanks are a valid resource for defining and understanding the genetic factors that contribute to drug response.

By Leigh MacMillan