DNA replication

DNA sequence visualization
November 12, 2015

Study helps clarify components of DNA ‘copy machine’

Vanderbilt investigators have generated a “parts list” for the molecular machinery that duplicates DNA each time a cell divides. The research has implications for cancer therapies that target components of this machinery.

By Leigh MacMillan
DNA sequence visualization
July 16, 2015

Study reveals how protein helps cells tolerate DNA damage

Vanderbilt and Stanford investigators have discovered how a protein that’s part of the DNA replication “machinery” helps cells tolerate DNA damage.

By Leigh MacMillan
May 23, 2014

Repair protein’s DNA recognition motif

Insights into the workings of DNA damage response proteins such as SMARCAL1 could suggest new ways to improve genome integrity and prevent cancer.

By Leigh MacMillan
May 9, 2014

Bypassing DNA damage

Studies of a human polymerase that replicates DNA have provided a complete kinetic and structural framework for understanding how the enzyme accurately bypasses DNA damage.

By VUMC News and Communications
November 7, 2013

VU study sheds new light on DNA replication

David Cortez, Ph.D., and his Vanderbilt colleagues report new findings that shed light on fundamental processes involved in DNA replication and have implications for cancer therapies that target these processes.

By Leigh MacMillan
January 23, 2013

New view of DNA processing ‘hub’

Structural studies reveal a new framework for understanding a central player in DNA processing.

By Leigh MacMillan