Hassane Mchaourab

January 6, 2022

Study explores how bacteria become drug resistant

Vanderbilt researchers have revealed more of the inner-workings of a two-stage “molecular motor” in the cell membrane that enables bacteria to become resistant to drugs.

By Bill Snyder
May 29, 2019

Study details regulation of a multi-drug transporter

P-glycoprotein distinguishes between chemicals that it will expel from a cell and inhibitors that block its action.

By Leigh MacMillan
May 9, 2019

New trans-institutional program to focus on genetic variations, disease

A new program at Vanderbilt will help researchers determine more precisely how genetic variations contribute to disease and what potentially can be done to put them right.

By Bill Snyder
x-ray of cell showing cell bodies
October 12, 2018

Cellular stress defense

The modular architecture of small heat-shock proteins contributes to the ability of these proteins to aid cells in responding to stress.

By Sanjay Mishra
July 19, 2018

Fueling the MATE transporter

Vanderbilt researchers used spectroscopy to understand how a drug transporter pumps drugs out of cells, findings that are important for developing novel anti-cancer and anti-bacterial drugs that can overcome drug resistance.

By Sanjay Mishra
May 24, 2018

Faculty meeting recognizes excellence in education, research and clinical service

During Wednesday’s Spring Faculty Meeting, Jeff Balser, M.D., Ph.D., dean of Vanderbilt University School of Medicine and President and CEO of Vanderbilt University Medical Center, highlighted the medical school’s rising stature among the country’s top-tier institutions.

By Bill Snyder
January 25, 2018

A cataract-heart connection

Studies of alpha-B crystallin in zebrafish could ultimately lead to improved treatment for cataracts and heart disease.
By Sanjay Mishra
March 16, 2017

Study catches ‘notorious’ drug pump in action

Researchers at Vanderbilt University Medical Center (VUMC) have mapped the conformational changes that occur in a protein “notorious” for pumping chemotherapeutic drugs out of cancer cells and blocking medications from reaching the central nervous system.
By Bill Snyder
July 14, 2016

Membrane fats impact drug transporter

New studies of a membrane transporter could explain antibiotic resistance – and lead to novel ways to combat it.
By Bill Snyder
February 5, 2016

Dynamics of a drug resistance transporter

Vanderbilt investigators are exploring the shape changes in a multidrug transporter to understand the mechanisms of antibacterial resistance.
By VUMC News and Communications
July 29, 2015

In a zebrafish’s eye

Vanderbilt investigators demonstrate that a certain eye lens protein is evolutionarily conserved between zebrafish and rat, suggesting that zebrafish can be used as a model system to understand eye lens disorders such as cataracts.
By Sanjay Mishra
October 23, 2014

New view of transporter dynamics

New insights to the workings of a protein that moves neurotransmitters across the nerve cell membrane could aid the design of more effective antidepressants.
By Bill Snyder
August 14, 2014

Team takes 4-D look at brain receptor’s role

Reporting last week in the journal Cell, researchers from Oregon Health and Science University, Harvard Medical School and Vanderbilt University describe the first “four-dimensional” picture of a brain receptor that plays a key role in learning and memory.
By Bill Snyder
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