inflammatory response

June 29, 2023

Persistent inflammatory state found in half of pediatric sepsis deaths: study

New research shows that about half of pediatric patients who died of sepsis over the past 20 years at Vanderbilt University Medical Center had evidence of an inflammatory state called persistent inflammation, immunosuppression and catabolism syndrome.

By Leigh MacMillan
March 28, 2023

Inflammation implicated in exfoliation syndrome

Computational genetics tools have implicated inflammatory pathways in exfoliation syndrome, the most common cause of secondary glaucoma, which can result in blindness.

By Leigh MacMillan
September 8, 2022

Immune cells drive beta cell loss in Type 2 diabetes

Vanderbilt researchers have discovered details of pancreatic beta cell loss — and potential therapeutic targets — during conditions of overnutrition, as occurs in obesity.

By Kelsey Pinckard
The study team included, from left, Mohammad Saleem, PhD, Lale Ertuglu, MD, Annet Kirabo, PhD, and Ashley Pitzer, PhD.
August 17, 2022

Researchers discover how salt increases blood pressure

A Vanderbilt research team has discovered that activation of a certain protein complex involved in the inflammatory response in immune cells contributes to salt-sensitive hypertension.

By Leigh MacMillan
C. Henrique Serezani, PhD, right, and colleagues, from left, Amondrea Blackman, Nathan Klopfenstein and Júlia Miranda Ribeiro Bazzano are studying the early events of the inflammatory response to infection.
December 10, 2020

Study details early events of inflammatory response

Vanderbilt University Medical Center investigators have identified a key molecular player in the early events of the inflammatory response to infection. The findings suggest new therapeutic possibilities for enhancing the inflammatory response to protect against pathogens and for blocking inflammation gone awry in diseases like arthritis and atherosclerosis.

By Leigh MacMillan