Martin Egli

October 18, 2018

Grant enhances study of new chemotherapy targets

Vanderbilt chemists have been awarded $7.2 million over the next five years from the National Cancer Institute to lead an initiative to better understand how a combination chemotherapy for breast cancer targets DNA.

By Tom Wilemon
July 25, 2017

Altered metabolism and disease

Vanderbilt researchers report a structure of a human metabolic enzyme bound to its substrate 17alpha-hydroxyprogesterone.

By VUMC News and Communications
model of DNA double helix
January 22, 2016

Faulty building blocks in DNA

An enzyme that builds DNA is able to insert the wrong building blocks, which could generate mutations.

By Bill Snyder
May 9, 2014

Bypassing DNA damage

Studies of a human polymerase that replicates DNA have provided a complete kinetic and structural framework for understanding how the enzyme accurately bypasses DNA damage.

By VUMC News and Communications
November 21, 2012

Carcinogenic chemicals cramp DNA

Researchers have determined how a DNA lesion caused by exposure to chemicals may spark cancer formation.

By VUMC News and Communications
June 8, 2012

DNA: From modification to mutation

Understanding how an environmental hazard damages DNA may shed light on processes of tumor formation.

By Leigh MacMillan
October 7, 2011

Fungus toxin gets in the way in DNA

Structural studies are providing insight to how aflatoxin – a toxin produced by fungi – contributes to cancer development.
By Leigh MacMillan
February 15, 2011

Fluorine aids gene silencing

Modifying a form of RNAs may improve their efficacy for research and medical uses.
By VUMC News and Communications