Molecular Cell Archive — Page 1 of 1

Madison Adolph, PhD, left, David Cortez, PhD, and Archana Krishnamoorthy are studying fundamental processes involved in DNA replication.
July 22, 2021

Researchers discover that protein switches functions to regulate DNA replication

Vanderbilt biochemists have discovered what the DNA damage response protein RADX does — and how it does it.

By Leigh MacMillan
Stylized close-up of colorful molecular DNA double helices against a blue background.
February 4, 2021

Gene network for leukemia factor

A new method speeds the analysis of factors that control gene expression from days to minutes, allowing researchers to uncover new targets for cancer treatment.

By Leigh MacMillan
Portrait of Manuel Ascano, Ph.D., smiling in a biochemistry laboratory, with lab equipment and shelves visible in the background.
May 7, 2020

New method captures early viral-host protein interactions

Researchers have developed a method to identify the primary interactions between incoming viral RNA genomes and host proteins.

By Bill Snyder
Abstract visualization of DNA sequencing data, with multicolored nucleotide letters and fluorescent waveform peaks reflected across a digital data surface.
February 6, 2020

New tool probes gene regulation

Vanderbilt biochemists got unexpected results when they used their new approach to explore the role of DNA methylation in gene regulation.

By Leigh MacMillan
Head-and-shoulders portrait of a man in a dark suit and patterned tie against a brick wall.
July 20, 2017

Study identifies protein’s role in chemotherapy resistance

Researchers at Vanderbilt University Medical Center (VUMC) have discovered a protein that may lead to a new way to prevent resistance and improve outcomes for patients whose cancers have mutations in the tumor suppressor gene BRCA2.

By Bill Snyder
DNA sequence visualization
November 12, 2015

Study helps clarify components of DNA ‘copy machine’

Vanderbilt investigators have generated a “parts list” for the molecular machinery that duplicates DNA each time a cell divides. The research has implications for cancer therapies that target components of this machinery.

By Leigh MacMillan