NCATS

window in the process of freezing over

Plasmin prevents muscle ‘hardening’ after injury: study

Vanderbilt researchers have made the surprising discovery that the protease plasmin, known for its clot-busting role in the blood, protects soft tissue from turning to bone after severe injuries and certain orthopaedic surgeries.

Electrical circuit with various components interfaced with a brain

Blood-brain barrier on a chip sheds new light on “silent killer”

A new microfluidic device containing human cells that faithfully mimics the behavior of the blood-brain barrier is providing new insights into brain inflammation, the silent killer.

Reducing antidepressants’ side effects

Vanderbilt investigators have discovered how antidepressant medicines that block serotonin uptake can increase bleeding risk.

tug-of-rope pair

VUMC investigators find pathogens work together to infect host

Pseudomonas aeruginosa and Staphylococcus aureus — two pathogens that frequently co-infect the lungs of patients with cystic fibrosis — appear to cooperate with each other, Vanderbilt investigators have discovered. When pseudomonas is starved for metal by the host, it shuts down the production of factors that would normally kill staph, promoting a co-infection.

Single-cell study of tumor samples

A new method for analyzing cells in fixed biopsy tissues from patients by guide personalized treatment strategies for cancer.

Sleep issues in children with diabetes

Lengthening sleep duration and reducing sleep disturbances in children with type 1 diabetes may improve diabetes outcomes and reduce parental stress.

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