NIGMS

March 28, 2019

Unraveling endocytosis

New discoveries by Jason MacGurn and colleagues further understanding of the complex machinery that cells use take up substances from outside the cell.

By VUMC News and Communications
February 28, 2019

Achilles’ heel for kidney cancer

The discovery that kidney cells with mutations in a certain gene are sensitive to therapies called PI3K inhibitors opens new opportunities for applying precision medicine to cancer treatment.

By VUMC News and Communications
February 28, 2019

Personalized pain management

Understanding how natural brain chemicals with pain-relieving properties interact with administered opioids may guide personalized approaches for pain management.

By VUMC News and Communications
Kareem Mohni, PhD, left, and David Cortez, PhD, have discovered a new DNA repair pathway that guards against genomic mutations.
February 28, 2019

Novel DNA repair mechanism preserves genome integrity: study

Biochemistry investigators at Vanderbilt have discovered a new DNA repair mechanism that prevents gene mutations during DNA replication.

By Leigh MacMillan
February 14, 2019

The yin and yang of cell signaling

Larry Marnett and colleagues have explored the role of two enzymes in metabolizing molecules associated with cell proliferation, inflammatory processes and neurological diseases.

By Sanjay Mishra
January 17, 2019

Signals from the “conveyor belt”

Vanderbilt researchers propose that cellular signaling pathways are amplified by a “conveyor belt” mechanism that exchanges active and inactive enzymes.

By Bill Snyder
January 17, 2019

DNA’s on/off switch

DNA-binding “switches” represent a fundamentally new method of communication between DNA-processing enzymes, Vanderbilt researchers propose.
By Bill Snyder
December 13, 2018

The exocyst dynamo

New methods have revealed details of vesicle trafficking in cells and are applicable to any protein complexes, potentially revolutionizing our understanding of cell dynamics.
By Bill Snyder
November 29, 2018

Analyzing single-cell landscapes

Vanderbilt researchers have developed a new tool for quantifying data from single-cell studies.
By Leigh MacMillan
November 8, 2018

Evading cell death

Stress granules that form in response to cellular stress help cancer cells survive and develop resistance to treatment.
By VUMC News and Communications
October 1, 2018

Probing the genetics of fibroids

A new study identified multiple genetic locations associated with the size and number of uterine fibroids — common non-cancerous uterine tumors.
By Leigh MacMillan
September 27, 2018

Fat tissue’s “iron sink”

Alyssa Hasty and colleagues demonstrated that immune cells called macrophages act in fat tissue to store iron and prevent iron toxicity.
By Sanjay Mishra
September 5, 2018

Unleashing TIGER on small RNAs

Vanderbilt investigators have developed a new analytical tool to identify, quantify and analyze small RNAs.
By Leigh MacMillan
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