NINDS

January 24, 2023

How arterial “stiffness” may impair cognition

New findings from Vanderbilt neurologists suggest that cardiovascular disease may increase the spaces surrounding blood vessels in the brain and lead to cognitive decline.

By Kelsey Pinckard
November 8, 2022

Alzheimer’s risk factor and cognition

Vanderbilt researchers found that a protein with roles in innate immunity worsens memory at baseline in carriers of APOE-e4, the strongest genetic risk factor for Alzheimer’s disease, further implicating neuroinflammation in cognitive decline.

By Leigh MacMillan
October 6, 2022

Gene tied to childhood epilepsy

Data drawn from four unrelated patients with a childhood epilepsy syndrome — and from in vitro and in vivo studies — link novel variants in a GABA transporter gene to seizure activity, Vanderbilt researchers reported.

By Paul Govern
September 22, 2022

Nerve cells and cancer progression

Immature nerves and neural precursor cells increase in density as a type of premalignant tumor in the pancreas progresses to invasive disease, suggesting that blocking these cells may arrest malignant progression.

By Leigh MacMillan
Maria Hadjifrangiskou, PhD, Connor Beebout, PhD, and colleagues are studying why the bacterium E. coli is so tenacious.
August 25, 2022

Study describes how E. coli co-opts cells, causes recurrent UTIs

Researchers at Vanderbilt University Medical Center have discovered why the uropathogenic bacterium E. coli, the leading cause of urinary tract infections, is so tenacious; their findings could lead to new ways to prevent recurrent UTIs.

By Bill Snyder
May 9, 2022

Gene variants and transplant drug dose

Genotyping multiple enzymes that metabolize the immunosuppressive drug tacrolimus — common used for lung transplant recipients — is important for correct dosing of the drug, Vanderbilt researchers found.

By Leigh MacMillan
April 21, 2022

Youthful healing for burn wounds

Topical treatment of burns with an immunosuppressive drug counteracted the negative effects of aging on wound healing, Vanderbilt researchers have discovered.
By Sarah E. Glass
November 11, 2021

The power of white matter

Using a novel analysis of fMRI data, Vanderbilt researchers discovered intriguing patterns of signals in the brain’s white matter, the “conduit” for relaying signals between different brain regions.
By Bill Snyder
September 20, 2021

Brain circuits in schizophrenia

Vanderbilt psychiatrists are probing brain circuit hyperactivity implicated in schizophrenia, with the idea that normalizing the hyperactivity may improve cognitive processes.
By Leigh MacMillan
September 2, 2021

White matter and schizophrenia

Patients with schizophrenia have functional changes in the white matter of the brain, Vanderbilt researchers have discovered, which may contribute to impaired working memory and processing speed.
By Emily Stembridge
August 9, 2021

Sudden death from deep in the brain?

Vanderbilt neurologists found altered excitability in deep brain structures that they note may drive respiratory dysfunction and sudden death in a rare form of epilepsy.
By Paul Govern
May 25, 2021

Heat for hypertension in autonomic failure

Heat therapy could offer a novel nonpharmacologic approach for treating the overnight hypertension that affects patients with autonomic failure.
By Leigh MacMillan
February 9, 2021

Imaging guidance for nerve repair

A noninvasive, quantitative MRI method could be used after surgical repair of traumatic peripheral nerve injury to help clinicians make decisions about whether additional surgical interventions are needed.
By Leigh MacMillan
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