pathology microbiology and immunology

July 16, 2021

Study identifies monoclonal antibodies that may neutralize many norovirus variants

Researchers at Vanderbilt University Medical Center (VUMC) and the Baylor College of Medicine in Houston, Texas, have taken a big step toward developing targeted treatments and vaccines against a family of viruses that attacks the gastrointestinal tract.

By Bill Snyder
May 24, 2021

Therapeutic antibodies for hantavirus

Vanderbilt Vaccine Center researchers have isolated monoclonal antibodies against hantaviruses, an emerging source of human disease with pandemic potential.

By Bill Snyder
May 12, 2021

Heparin, platelets discouraged as treatment for blood clots after COVID vaccine

Heparin and platelets are discouraged as treatment for patients who develop blood clots in the brain and low platelet counts 6-15 days after receiving Johnson & Johnson’s Janssen COVID-19 vaccine, following a clinical investigation review of 12 U.S. cases conducted by the CDC and institutions including Vanderbilt University Medical Center.

By Craig Boerner
The team studying the regulation of innate immune response includes (front row, from left) Yang Zhao, Antiana Richardson, (back row, from left) John Karijolich, PhD, Xiang Ye and William Dunker.
May 6, 2021

Study finds that regulatory protein prevents signaling that triggers cell death

A protein implicated in neurodegenerative diseases including amyotrophic lateral sclerosis prevents the activation of an innate immune response that leads to cell death, Vanderbilt researchers have discovered.

By Leigh MacMillan
From left, Kimryn Rathmell, MD, PhD, Bradley Reinfeld, Matthew Madden and Jeffrey Rathmell, PhD, have discovered that immune cells — not cancer cells — are the major glucose consumers in the tumor microenvironment, upending a century-old observation.
April 7, 2021

Study revises understanding of cancer metabolism

Tumors consume glucose at high rates, but a team of Vanderbilt researchers has discovered that cancer cells themselves are not the culprit, upending models of cancer metabolism that have been developed and refined over the last 100 years.

By Leigh MacMillan
April 1, 2021

Novel way to neutralize Rift Valley Fever Virus

The discovery of monoclonal antibodies that neutralize Rift Valley Fever Virus — an emerging infection with pandemic potential — lays the foundation for future therapeutic antibody development.

By Bill Snyder
March 25, 2021

Team studies new use for pulmonary hypertension drug

An FDA-approved medication enhances the function of T regulatory cells (Treg), a class of immune cells that restrains the immune response, Vanderbilt investigators have discovered.
By Leigh MacMillan
March 23, 2021

Prostate cancer microenvironment

Distinct cancer-associated fibroblasts in the prostate tumor microenvironment may influence tumor progression and could point to new therapeutic targets.
By Leigh MacMillan
March 8, 2021

Temperature, newts and a skin-eating fungus

Salamanders are more sensitive to a skin-eating fungus at colder temperatures, pointing to locations of North America where pathogen invasion is most likely.
By Leigh MacMillan
February 23, 2021

Calcification after severe injury

Vanderbilt researchers have linked bone-related complications of severely injured patients — findings that could help minimize these complications.
By Emily Stembridge
February 18, 2021

Seegmiller named to new pathology, laboratory medicine leadership posts

Adam Seegmiller, MD, PhD, has been named the inaugural vice chair for Clinical Affairs in the Department of Pathology, Microbiology and Immunology as well as executive medical director of the newly formed Pathology and Laboratory Medicine — Clinical Service Center.
By Leigh MacMillan
February 18, 2021

VUMC postdoctoral scientist named HHMI Hanna Gray Fellow

Valeria Reyes Ruiz, PhD, a postdoctoral fellow in the Department of Pathology, Microbiology and Immunology, has been selected as a 2020 Hanna Gray Fellow by the Howard Hughes Medical Institute (HHMI).
By Leigh MacMillan
February 8, 2021

Key factors in HIV-1 replication

HIV-1, the virus that causes AIDS, exploits inositol phosphates in T cells to aid its own assembly and maturation — suggesting that targeting inositol phosphate binding could inhibit HIV-1 replication.
By Anivarya Kumar
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