penicillin allergy

July 17, 2023

World-first clinical trial to help millions with penicillin allergies

Many low-risk patients with a penicillin allergy were able to have their penicillin allergy label removed through a simple procedure known as “direct oral challenge” as part of a world-first multicenter randomized control trial known as the Penicillin Allergy Clinical Decision Rule (PALACE) study.

By Craig Boerner
February 16, 2023

Penicillin allergy test recommended for pregnant women

Vanderbilt experts say getting rid of unnecessary penicillin allergy labels allows women to receive better treatments for common infections during pregnancy and delivery.

By Kylie Avery
September 29, 2022

Penicillin delabeling initiative expanding to more patient care areas

Efforts to correct mistaken or outdated penicillin allergy records are destined to spread to more patient care areas at Vanderbilt University Medical Center.

By Paul Govern
March 10, 2022

ICU study confirms safety of delabeling penicillin allergies

A Vanderbilt study shows that physicians can safely identify and disprove low-risk penicillin allergies using an oral amoxicillin challenge in consenting patients, even those in the intensive care unit who are recovering from critical illness.

By Nancy Humphrey
October 1, 2020

Genes spell penicillin allergy risk

Studies using large DNA biobanks revealed genetic variants associated with penicillin allergy, the most common type of drug-induced allergic reaction.

By Paul Govern
May 6, 2020

New rule outlines when to challenge a penicillin allergy

According to the U.S. Centers for Disease Control and Prevention, fewer than 1% of the population is truly allergic to penicillin. The rest were never allergic to begin with or have outgrown their allergy — an estimated 80% of people with penicillin allergy lose their sensitivity to the drug within 10 years.

By Paul Govern
October 17, 2019

Effort to remove penicillin allergy labels seeing success

A program in the Medical Intensive Care Unit has successfully removed penicillin allergy labels from more than 45 inpatients at high risk to receive antibiotics, but whose penicillin allergies were low risk.
By Nancy Humphrey