Research

The team studying the regulation of innate immune response includes (front row, from left) Yang Zhao, Antiana Richardson, (back row, from left) John Karijolich, PhD, Xiang Ye and William Dunker.
May 6, 2021

Study finds that regulatory protein prevents signaling that triggers cell death

A protein implicated in neurodegenerative diseases including amyotrophic lateral sclerosis prevents the activation of an innate immune response that leads to cell death, Vanderbilt researchers have discovered.

By Leigh MacMillan
April 28, 2021

Regev receives Vanderbilt Prize in Biomedical Science

Aviv Regev, PhD, an internationally known computational biologist and executive vice president of Genentech Research and Early Development (gRED), is the recipient of the 2021 Vanderbilt Prize in Biomedical Science, officials at Vanderbilt University Medical Center announced this week.

By Bill Snyder
April 19, 2021

VUMC aids national effort to repurpose drugs for COVID-19

Vanderbilt University Medical Center (VUMC) has been named Data Coordinating Center (DCC) for a nationwide platform of studies aimed at “repurposing” existing drugs to treat mild to moderate symptoms of COVID-19.

By Bill Snyder
Benjamin Brown, left, Jens Meiler, PhD, Zhenfang Du, PhD, and colleagues are studying the functional consequences of genetic mutations and how those changes can drive cancerous growth.
April 8, 2021

Personalized Structural Biology aids cancer treatment decisions

Cancer specialists at Vanderbilt University Medical Center, in partnership with biochemists and structural biologists across the Vanderbilt University campus, are taking “personalized” cancer therapy to a new level.

By Bill Snyder
From left, Kimryn Rathmell, MD, PhD, Bradley Reinfeld, Matthew Madden and Jeffrey Rathmell, PhD, have discovered that immune cells — not cancer cells — are the major glucose consumers in the tumor microenvironment, upending a century-old observation.
April 7, 2021

Study revises understanding of cancer metabolism

Tumors consume glucose at high rates, but a team of Vanderbilt researchers has discovered that cancer cells themselves are not the culprit, upending models of cancer metabolism that have been developed and refined over the last 100 years.

By Leigh MacMillan
Deanna Edwards, PhD, left, Jin Chen, MD, PhD, and colleagues are studying a new therapeutic strategy for triple-negative breast cancer.
April 1, 2021

Breast cancer cells ‘steal’ nutrients from immune cells: study

Triple-negative breast cancer cells engage in a “glutamine steal” — outcompeting T cells for the nutrient glutamine and impairing their ability to kill tumor cells, Vanderbilt researchers have discovered.

By Leigh MacMillan
April 1, 2021

Study shows new COVID target could improve vaccines

Despite an impressive vaccination effort that exceeds 2 million shots a day, rates of COVID-19 are again on the rise in several parts of the United States, as is the spread of highly transmissible variants of the virus.
By Bill Snyder
March 31, 2021

Physician-scientists Aliyu, Tindle elected to ASCI

Vanderbilt’s Muktar Aliyu, MBBS, MPH, DrPH, and Hilary Tindle, MD, MPH, will be inducted this year into the American Society for Clinical Investigation (ASCI), an elite honor society of physician-scientists from the upper ranks of academic medicine and industry.
By Bill Snyder
March 29, 2021

NYU’s Tsien to discuss brain plasticity at next Discovery Lecture

Richard Tsien, PhD, director of the Neuroscience Institute at NYU Langone Medical Center, will deliver the next web-based Discovery Lecture.
By Leigh MacMillan
March 25, 2021

Team studies new use for pulmonary hypertension drug

An FDA-approved medication enhances the function of T regulatory cells (Treg), a class of immune cells that restrains the immune response, Vanderbilt investigators have discovered.
By Leigh MacMillan
March 18, 2021

Study to assess allergic reactions to COVID vaccines

Vanderbilt University Medical Center is recruiting volunteers for a randomized controlled phase 2 clinical trial to help determine the prevalence of systemic allergic reactions (SARS) to the two-dose COVID-19 mRNA vaccines made by Pfizer-BioNTech and Moderna.
By Bill Snyder
March 18, 2021

Vanderbilt research played key role in new lung screen guidelines

The U.S. Preventive Services Task Force (USPSTF) has formally recommended two changes that will nearly double the number of people eligible for lung cancer screening by lowering the age from 55 to 50 and reducing the number of smoking history pack years from 30 to 20.
By Tom Wilemon
March 15, 2021

Artificial intelligence calculates suicide attempt risk at VUMC

A machine learning algorithm that predicts suicide attempt recently underwent a prospective trial at the institution where it was developed, Vanderbilt University Medical Center.
By Paul Govern
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