RNA viruses

The team studying the regulation of innate immune response includes (front row, from left) Yang Zhao, Antiana Richardson, (back row, from left) John Karijolich, PhD, Xiang Ye and William Dunker.

Study finds that regulatory protein prevents signaling that triggers cell death

A protein implicated in neurodegenerative diseases including amyotrophic lateral sclerosis prevents the activation of an innate immune response that leads to cell death, Vanderbilt researchers have discovered.

Cellular antiviral defenses

A cellular RNA quality control mechanism was known to restrict replication of RNA viruses. Vanderbilt researchers have discovered it is also antiviral against DNA viruses.

New method captures early viral-host protein interactions

Researchers have developed a method to identify the primary interactions between incoming viral RNA genomes and host proteins.