TGF-beta signaling in the kidney was thought to be a target for reducing renal fibrosis, but Vanderbilt researchers report that fibrosis still occurs in the absence of TGF-beta signaling.

A protein that degrades the “matrix” between cells participates in the development of lung metastases from primary breast cancer in mouse models and may be a good target for breast cancer treatment.

A new mouse model offers insight into the signaling pathways that control oral cancers – and a platform for testing anticancer therapeutics.

A novel molecular “conversation” regulates kidney fibrosis – the final result of end-stage chronic kidney disease – suggesting new treatment options for this currently irreversible process.

Blocking a serotonin receptor may provide a novel therapy for heart valve disease.

Targeting immune system proteins may keep prostate cancer from spreading to bone.

Cellular pathways altered by chronic exposure to cigarette smoke may reveal new biomarkers to assess smoking-induced lung cancer risk.