Migraine mutations reveal clues to biological basis of disorder
Fifteen percent to 20 percent of people worldwide suffer from migraines – excruciating headaches often presaged by dramatic sensations, or "auras." By studying a rare, inherited form of migraine, researchers at Vanderbilt University Medical Center have found clues to the biological basis of the painful, debilitating disorder. In the Proceedings of the National Academy of Sciences, Alfred George Jr., M.D., and colleagues report that genetic mutations linked to this rare form of familial migraine alter the function of sodium channels – protein "tunnels" through brain cell membranes involved in the electrical conduction of nerve impulses.
By VUMC News and Communications