Wenbiao Chen

Immune cells drive beta cell loss in Type 2 diabetes

Vanderbilt researchers have discovered details of pancreatic beta cell loss — and potential therapeutic targets — during conditions of overnutrition, as occurs in obesity.

Insulin in vials

Fighting type 2 diabetes with FGF1

The growth factor FGF1 induces the growth of new insulin-producing beta cells and may help treat type 2 diabetes.

In a zebrafish’s eye

Vanderbilt investigators demonstrate that a certain eye lens protein is evolutionarily conserved between zebrafish and rat, suggesting that zebrafish can be used as a model system to understand eye lens disorders such as cataracts.

A “CRISPR” way to study disease

Using revolutionary CRISPR technology, Vanderbilt investigators have developed a fast and simple method to simultaneously turn off multiple genes in order to study complex diseases.

Tiny model of diabetes

Vanderbilt University researchers have created a zebrafish model of skeletal muscle insulin resistance that could help improve diabetes treatment.

Setting traps to probe gene function

A new method for creating genetic mutations that can be activated at certain times or in specific tissues will enable studies to probe gene function.