Wnt signaling

June 4, 2020

Protecting the injured kidney

Leslie Gewin and colleagues have upended conventional dogma about Wnt/beta-catenin signaling in the kidney, finding that it protects against chronic kidney disease rather than promoting it.

By Leigh MacMillan
March 5, 2020

Clues to lung injury in preterm babies

Jennifer Sucre and colleagues have discovered a factor that contributes to the pathological changes of bronchopulmonary dysplasia, the most common complication of preterm birth.

By Leigh MacMillan
August 27, 2019

A “rheostat” for cancer signals

Jason MacGurn and colleagues have characterized a “rheostat” that sets WNT pathway signaling in breast cancer cells.

By Sanjay Mishra
April 5, 2018

Lung diseases share molecular signature

Lung diseases of infancy and aging share a molecular signature, pointing to a potential target for treatment and prevention.

By Leigh MacMillan
February 28, 2018

Structure of a stem cell niche

Understanding the specialized environment where stem cells reside is important for developing stem-cell based regenerative therapies.

By Leigh MacMillan
February 23, 2017

A target to heal tiny lungs

The protein beta-catenin may be a good target for therapies to treat lung disease that is a common complication of preterm birth.

By Leigh MacMillan
January 19, 2017

Colorectal cancer clues

Although cancers arising from different areas of the large intestine are heterogeneous, they appear to use similar important tumorigenic pathways.
By Leigh MacMillan
January 27, 2016

Wound-healing scaffolds

The elasticity of a scaffold used for healing skin wounds is a key factor in promoting regeneration versus scarring.
By Leigh MacMillan
October 16, 2015

Healing without scarring

Drugs that inhibit the Wnt signaling pathway can regenerate injured skin and may be useful in treating fibromatosis, degenerative joint disease and cancer.
By Sanjay Mishra
September 17, 2015

Heart repair factor

A signaling factor called Wnt10b is a novel target for optimizing cardiac repair after a heart attack.
By Yan Su
November 21, 2013

Therapeutic target for synovial sarcoma

Inhibitors of a signaling pathway that is critical to synovial sarcoma tumorigenesis may be useful treatments for this aggressive cancer.
By Leigh MacMillan
September 18, 2013

Fishing for new anti-cancer drugs

Vanderbilt investigators used an in vivo screen in zebrafish to identify a potential new anti-cancer drug.
By Leigh MacMillan
May 17, 2012

Long live the therapeutic stem cells

Enhancing stem cell survival is key to improving cell-based therapies for regenerative medicine, and a new drug could help.
By Leigh MacMillan