atherosclerosis Archives

The study could suggest ways to promote the transport of phospholipids and cholesterol out of macrophages, immune system cells that play key roles in all stages of atherosclerosis development.

Reminders for clinicians improve prescribing for high cholesterol

Mar. 23, 2023—A Vanderbilt study found that automated targeted reminders for clinicians helped increase prescribing of high intensity statins for patients with various atherosclerotic cardiovascular disease diagnoses, including coronary or peripheral artery disease and ischemic stroke.

The study found that chronically disrupted sleep and highly variable sleep durations night after night may increase the risk for atherosclerosis.

Study finds chronically disrupted sleep may increase risk for heart disease

Feb. 15, 2023—Vanderbilt research found that sleep irregularity — chronically disrupted sleep and highly variable sleep durations night after night — may increase the risk for atherosclerosis.

Study points to new ways to prevent, treat heart disease

Jan. 19, 2023—Vanderbilt researchers have confirmed the existence of an alternative pathway to atherosclerosis, a finding that may lead to new ways to prevent and treat cardiovascular disease.

Study suggests new mechanism for lipid transporter

Sep. 15, 2022—A new model suggests that a protein involved in the generation of high-density lipoprotein (HDL) works differently than previously thought.

Rheumatoid arthritis and heart disease: a common path

Aug. 25, 2022—An increase in certain antibodies in patients with rheumatoid arthritis can serve as a predictive biomarker for cardiovascular disease, Vanderbilt researchers have discovered.

There’s no slowing arterial stiffening

Mar. 29, 2022—Over 10 years, multiple healthy behaviors did not slow the progression of arterial stiffness, a risk factor for coronary artery disease, hypertension, stroke, atrial fibrillation and heart failure.

Potential protection from atherosclerosis

Aug. 19, 2021—Vanderbilt researchers have discovered a potential way to reduce atherosclerosis: blocking the modification of an HDL-associated enzyme by reactive molecules called isolevuglandins.

From left, MacRae Linton, MD, Huan Tao, MD, PhD, Jonathan Brown, MD, and colleagues have discovered a potential new target for preventing atherosclerosis.

Nature’s “recycler” could reduce heart disease risk: study

Jul. 8, 2021—Researchers at Vanderbilt University Medical Center have identified potential new targets for the prevention of atherosclerosis through the enhancement of autophagy, a natural process for recycling damaged cellular material.

NIH grant bolsters research on heart disease, cholesterol

Jan. 21, 2021—Thanks to major funding from the National Institutes of Health (NIH), researchers at Vanderbilt University Medical Center have made major inroads in understanding how high-density lipoprotein (HDL), commonly known as good cholesterol, in some cases may actually contribute to the development of atherosclerosis.

From left, Huan Tao, MD, PhD, Sean Davies, PhD, Jiansheng Huang, PhD, and MacRae Linton, MD, led the study that identified a potential new treatment for atherosclerosis.

‘Scavenger’ molecule may point to new atherosclerosis treatment

Aug. 20, 2020—A small-molecule “scavenger” that reduces inflammation and formation of atherosclerotic plaque in blood vessels in mice potentially could lead to a new approach for treating atherosclerosis in humans, according to researchers at Vanderbilt University Medical Center.

Soy food, metabolism and the microbiome

Jul. 27, 2020—Consumption of soy foods may shape the microbiome and protect against hypertension only in individuals with soy-responsive microbiota, Vanderbilt researchers have discovered.

A new contributor to atherosclerosis

Jan. 27, 2020—Sean Davies and colleagues are exploring lipid aldehydes produced during oxidative stress and their contribution to HDL dysfunction and atherosclerosis.