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Department of Biochemistry Archives

Molecular imaging of C. diff infection

Sep. 30, 2021—C. difficile — the leading cause of hospital-associated intestinal infections — induces a rapid influx of bile acids into the gut, which could provide a novel target for blocking infection.

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Expression atlas for cell regulators

Aug. 19, 2021—Vanderbilt researchers report a comprehensive tissue-specific atlas of protein and mRNA expression for p63 and p73, members of the p53 family signaling network that is the most frequent target of mutations in human cancers.

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Cortez named chair of Department of Biochemistry

Jul. 29, 2021—David Cortez, PhD, Richard N. Armstrong, PhD, Professor of Innovation in Biochemistry and professor of Biochemistry, has been appointed chair of the Department of Biochemistry.

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Researchers discover that protein switches functions to regulate DNA replication

Jul. 22, 2021—Vanderbilt biochemists have discovered what the DNA damage response protein RADX does — and how it does it.

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Osheroff elected to AAMC council leadership post

Jul. 22, 2021—Neil Osheroff, PhD, professor of Biochemistry and Medicine, has been elected to a leadership position for a council of the Association of American Medical Colleges (AAMC).

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Arrhythmia culprit: supertrafficking ion channel

Apr. 15, 2021—Charles Sanders, PhD, and colleagues show how a “supertrafficking” mutant potassium channel contributes to heart rhythm abnormalities.

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Gene network for leukemia factor

Feb. 4, 2021—A new method speeds the analysis of factors that control gene expression from days to minutes, allowing researchers to uncover new targets for cancer treatment.

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Cortez named interim chair of the Department of Biochemistry; York named Impossible Foods chief science officer

Dec. 8, 2020—David Cortez, PhD, Richard N. Armstrong Professor of Innovation in Biochemistry and professor of biochemistry, has been named interim chair in the Department of Biochemistry beginning Jan. 1, 2021.

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Assembling cell power plant machinery

Sep. 3, 2020—Tina Iverson and colleagues provide a structural view into the assembly of a protein machine essential for cellular energy production.

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Cellular antiviral defenses

Jul. 23, 2020—A cellular RNA quality control mechanism was known to restrict replication of RNA viruses. Vanderbilt researchers have discovered it is also antiviral against DNA viruses.

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Probing DNA damage repair

Jun. 18, 2020—After discovering a new mechanism for DNA damage repair last year, Vanderbilt biochemists now provide direct evidence for how it works.

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Probing innate immunity

May. 19, 2020—Manuel Ascano team validates an inhibitor of the cGAS-STING signaling pathway, which is important for cellular innate immunity against bacteria, viruses, and our own damaged DNA.

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