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Department of Biochemistry Archives

Probing innate immunity

May. 19, 2020—Manuel Ascano team validates an inhibitor of the cGAS-STING signaling pathway, which is important for cellular innate immunity against bacteria, viruses, and our own damaged DNA.

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New method captures early viral-host protein interactions

May. 7, 2020—Researchers have developed a method to identify the primary interactions between incoming viral RNA genomes and host proteins.

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A dual-purpose metabolic switch

May. 5, 2020—John York and colleagues have demonstrated that the protein Vip1 is a rare type of bifunctional enzyme: it can both synthesize and destroy key cellular signaling molecules.

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Cellular factor helps package flu genome

Mar. 23, 2020—New insights on influenza genome packaging could guide strategies for interfering with the virus’s life cycle and ability to cause infection.

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Loss of ‘Jedi’ alters neuron activity

Mar. 10, 2020—This is not the Jedi you're thinking of. This Jedi is a receptor that helps clear away dead neurons during development, and its loss changes the activity of dorsal root ganglia neurons, which could have implications for treating chronic pain.

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New tool probes gene regulation

Feb. 6, 2020—Vanderbilt biochemists got unexpected results when they used their new approach to explore the role of DNA methylation in gene regulation.

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Structural views of a C. diff toxin

Jan. 10, 2020—D. Borden Lacy and colleagues used cryo-electron microscopy to define the structure of a C. diff toxin, providing a framework for the design of novel therapeutics.

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Cell fate signaling

Dec. 17, 2019—A newly identified protein interaction that affects cell cycle regulation may be an attractive target for cancer therapy.

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Study examines HIV drug’s potential to treat Alzheimer’s

Dec. 12, 2019—A drug used to treat and prevent HIV/AIDS is showing promise as a potential therapy for Alzheimer’s disease.

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Osheroff elected IAMSE president

Dec. 12, 2019—Neil Osheroff, PhD, was elected president of the International Association of Medical Science Educators (IAMSE) and will serve from January 2020-December 2021.

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Imaging host-pathogen battle for metal

Oct. 31, 2019—An unprecedented view of bacterial products within infected tissues opens new opportunities to explore infection biology and devise novel therapeutic strategies.

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Completing DNA synthesis

Oct. 21, 2019—James Dewar and colleagues have identified a role for the enzyme topoisomerase II in reducing replication errors during the final stage of DNA synthesis.

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Recent Stories from VUMC News and Communications Publications

Betsy Williams has firsthand advice for parents on the fence about whether their adolescent children should be vaccinated for the common human papilloma virus (HPV), which can lead to six types of cancer.  Don’t hesitate. Do it.

Momentum

Betsy Williams has firsthand advice for parents on the fence about whether their adolescent children should be vaccinated for the common human papilloma virus (HPV), which can lead to six types of cancer. Don’t hesitate. Do it.

Keeping pace: Nashville, once a mid-size city with a Southern small-town feel, is experiencing explosive growth.

Vanderbilt Medicine

Keeping pace: Nashville, once a mid-size city with a Southern small-town feel, is experiencing explosive growth.

VUMC campus

VUMC campus

Vanderbilt University School of Medicine entrance

Vanderbilt University School of Medicine entrance

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