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Department of Biochemistry Archives

Gene network for leukemia factor

Feb. 4, 2021—A new method speeds the analysis of factors that control gene expression from days to minutes, allowing researchers to uncover new targets for cancer treatment.

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Cortez named interim chair of the Department of Biochemistry; York named Impossible Foods chief science officer

Dec. 8, 2020—David Cortez, PhD, Richard N. Armstrong Professor of Innovation in Biochemistry and professor of biochemistry, has been named interim chair in the Department of Biochemistry beginning Jan. 1, 2021.

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Assembling cell power plant machinery

Sep. 3, 2020—Tina Iverson and colleagues provide a structural view into the assembly of a protein machine essential for cellular energy production.

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Cellular antiviral defenses

Jul. 23, 2020—A cellular RNA quality control mechanism was known to restrict replication of RNA viruses. Vanderbilt researchers have discovered it is also antiviral against DNA viruses.

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Probing DNA damage repair

Jun. 18, 2020—After discovering a new mechanism for DNA damage repair last year, Vanderbilt biochemists now provide direct evidence for how it works.

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Probing innate immunity

May. 19, 2020—Manuel Ascano team validates an inhibitor of the cGAS-STING signaling pathway, which is important for cellular innate immunity against bacteria, viruses, and our own damaged DNA.

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New method captures early viral-host protein interactions

May. 7, 2020—Researchers have developed a method to identify the primary interactions between incoming viral RNA genomes and host proteins.

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A dual-purpose metabolic switch

May. 5, 2020—John York and colleagues have demonstrated that the protein Vip1 is a rare type of bifunctional enzyme: it can both synthesize and destroy key cellular signaling molecules.

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Cellular factor helps package flu genome

Mar. 23, 2020—New insights on influenza genome packaging could guide strategies for interfering with the virus’s life cycle and ability to cause infection.

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Loss of ‘Jedi’ alters neuron activity

Mar. 10, 2020—This is not the Jedi you're thinking of. This Jedi is a receptor that helps clear away dead neurons during development, and its loss changes the activity of dorsal root ganglia neurons, which could have implications for treating chronic pain.

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New tool probes gene regulation

Feb. 6, 2020—Vanderbilt biochemists got unexpected results when they used their new approach to explore the role of DNA methylation in gene regulation.

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Structural views of a C. diff toxin

Jan. 10, 2020—D. Borden Lacy and colleagues used cryo-electron microscopy to define the structure of a C. diff toxin, providing a framework for the design of novel therapeutics.

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