Department of Medicine

Protecting the injured kidney

Leslie Gewin and colleagues have upended conventional dogma about Wnt/beta-catenin signaling in the kidney, finding that it protects against chronic kidney disease rather than promoting it.

Remdesivir helps reduce COVID-19 recovery time: study

The investigational antiviral drug remdesivir can shorten the time to recovery in adults hospitalized with COVID-19, according to preliminary results of a clinical trial published last month in The New England Journal of Medicine.

Research examines genetics of problematic alcohol use

Alcohol use disorder and problematic drinking are genetically correlated with substance use, certain psychiatric illnesses and other neuropsychiatric traits, according to a study involving Vanderbilt University Medical Center researchers.

Multinational consortium reports COVID-19 impact on cancer patients

People with cancer sickened by COVID-19 have a crude death rate of 13%, according to the largest series of data released thus far from a multinational perspective. The data on more than 900 patients, published May 28 in The Lancet and simultaneously presented at ASCO20 Virtual, also revealed cancer-specific factors associated with increased mortality.

Interventions such as daily spontaneous waking trials can help patients avoid injuries associated with intensive care.

Study to test cognitive rehab therapy for ICU survivors

Vanderbilt University Medical Center will study adult survivors of medical and surgical intensive care at high risk for long-term cognitive impairment to see if computerized cognitive rehabilitation (CCR) is effective in improving cognition in ICU survivors who often have trouble doing complex tasks, maintaining their finances and staying employed.

Target trials support drug safety in pregnant patients

Out of concern for fetal safety, pregnant people have typically been excluded from drug trials. And when human health is on the line, drug studies assessing fetal safety in animal models may be viewed as far from definitive.

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