Division of Clinical Pharmacology Archives
A new mechanism for lupus
Aug. 30, 2022—Vanderbilt researchers describe a new mechanism for the most common form of lupus and suggest a new treatment approach to this autoimmune disease.
Researchers discover how salt increases blood pressure
Aug. 17, 2022—A Vanderbilt research team has discovered that activation of a certain protein complex involved in the inflammatory response in immune cells contributes to salt-sensitive hypertension.
Genotype-specific blood counts
Aug. 11, 2022—Vanderbilt researchers report genotype-specific reference ranges to improve interpretation of laboratory blood results in African Americans with a common gene variant that lowers white blood cell counts.
Longtime division leader earns degree, accolades
Jul. 21, 2022—Vanderbilt's Amy Shelton, MS, has been awarded a Master of Science Degree in Research Administration with Honors from the Johns Hopkins University Krieger School of Arts and Sciences.
Preempting sudden cardiac death
Jul. 7, 2022—A technique to characterize all variants in genes associated with arrhythmia could improve the ability to identify and preemptively treat individuals at risk for sudden cardiac death.
Study shows genotype leads to discontinued, decreased medication
Jun. 29, 2022— by Jill Clendening Patients whose race is recorded as Black in their electronic health record (EHR) are more likely to have azathioprine, an immunosuppressant medication, discontinued or its dose reduced because their laboratory results show a low white blood cell count. This lab finding was not a factor of race, but instead was linked...
BMI genetics influence heart function
Jun. 16, 2022—Vanderbilt researchers have discovered that a genetic predisposition to elevated body mass index increases the risk of diastolic dysfunction — a cardiac condition that can lead to heart failure.
Peptides promote AFib arrhythmia
Apr. 11, 2022—Peptide oligomers have detrimental metabolic effects and cause pro-arrhythmic electrophysiological changes in heart atria, suggesting they may contribute to atrial fibrillation.
VUMC researchers find clue to drug-induced arrhythmias
Feb. 24, 2022—Vanderbilt University Medical Center researchers have made a fundamental discovery about how the heart compensates for genetic variations that otherwise could trigger abnormal and potentially fatal heart rhythms.
Probing statin-associated diseases with genetics
Jul. 12, 2021—Vanderbilt researchers used genetics tools and biobanks with linked electronic health records to explore the associations between statins and noncardiovascular diseases.
Heat for hypertension in autonomic failure
May. 25, 2021—Heat therapy could offer a novel nonpharmacologic approach for treating the overnight hypertension that affects patients with autonomic failure.
Codeine metabolizer status in clinical practice
Apr. 5, 2021—Vanderbilt researchers have developed a response score using genetic and clinical information to aid prescribing of the widely used pain medication codeine.
