Division of Clinical Pharmacology Archives
Signaling pathways in liposarcomas
Jul. 25, 2023—A broad bioinformatics approach revealed that Hedgehog signaling is upregulated in dedifferentiated liposarcoma, suggesting this pathway may be an early indicator of poor prognosis and a potential therapeutic target.
Magnesium deficiency and blood pressure
Jun. 26, 2023—Dietary magnesium depletion in a mouse model activated inflammatory pathways and molecules that promote hypertension, suggesting that increased magnesium consumption may be beneficial for reducing the prevalence of hypertension.
Targeting calcium handling in A-fib
Jun. 8, 2023—The drug ent-verticilide reduced A-fib incidence and duration in an animal model, suggesting it may be a viable therapeutic option.
Study evaluates polygenic risk score for prostate cancer risk prediction
Mar. 16, 2023—A Vanderbilt study found that prostate cancer polygenic risk score has limited utility for enhancing prostate cancer screening.
Anti-nausea drug response in children
Jan. 10, 2023—Genetic variation in a metabolic enzyme was not associated with response to the anti-nausea drug odansetron in children, Vanderbilt researchers report.
VUMC mourns loss of noted hypertension expert Elijovich
Oct. 28, 2022—Fernando Elijovich, MD, professor of Medicine in the Division of Clinical Pharmacology at Vanderbilt University Medical Center, died in Nashville on Oct. 21. He was 77.
A new mechanism for lupus
Aug. 30, 2022—Vanderbilt researchers describe a new mechanism for the most common form of lupus and suggest a new treatment approach to this autoimmune disease.
Researchers discover how salt increases blood pressure
Aug. 17, 2022—A Vanderbilt research team has discovered that activation of a certain protein complex involved in the inflammatory response in immune cells contributes to salt-sensitive hypertension.
Genotype-specific blood counts
Aug. 11, 2022—Vanderbilt researchers report genotype-specific reference ranges to improve interpretation of laboratory blood results in African Americans with a common gene variant that lowers white blood cell counts.
Longtime division leader earns degree, accolades
Jul. 21, 2022—Vanderbilt's Amy Shelton, MS, has been awarded a Master of Science Degree in Research Administration with Honors from the Johns Hopkins University Krieger School of Arts and Sciences.
Preempting sudden cardiac death
Jul. 7, 2022—A technique to characterize all variants in genes associated with arrhythmia could improve the ability to identify and preemptively treat individuals at risk for sudden cardiac death.
Study shows genotype leads to discontinued, decreased medication
Jun. 29, 2022— by Jill Clendening Patients whose race is recorded as Black in their electronic health record (EHR) are more likely to have azathioprine, an immunosuppressant medication, discontinued or its dose reduced because their laboratory results show a low white blood cell count. This lab finding was not a factor of race, but instead was linked...
