inflammation

November 6, 2025

Inflammatory marker could predict response to therapy in bladder pain syndrome

Patients with chronic bladder pain syndrome who had higher baseline levels of the inflammatory molecule IL-1beta had greater overall improvement following cognitive behavioral therapy.

By Georgia Caso
The team studying how to control sepsis in the lungs and kidneys includes, from left, Huan Qiao, MD, PhD Jacek Hawiger, MD, PhD, Jozef Zienkiewicz, PhD, and Yan Liu, MD, MS. (photo by Erin O. Smith)
October 22, 2025

New sepsis therapy developed at VUMC edges closer to the clinic

Jacek Hawiger and his colleagues report that a “peptide genomic therapy” given in combination with an antibiotic nearly doubles survival rates from sepsis in an animal model, compared to treatment with antibiotic alone.

By Bill Snyder
June 4, 2025

VUMC team finds potential target to slow atherosclerosis

The research findings suggest that regulating the immune response to high cholesterol through the protein CaMK4 could enhance blood vessel repair and slow atherosclerosis progression.

By Guillermo Sanchez, PhD
November 26, 2024

What’s all the tuft about?

Vanderbilt researchers used advanced imaging techniques to detail the microscopic structure of intestinal tuft cells, highlighting their unique organization of the structural protein actin.

By Amanda Ruelas
September 20, 2024

Fever drives enhanced activity, mitochondrial damage in immune cells

The mechanistic understanding of how cells respond to heat could explain how chronic inflammation contributes to the development of cancer.

By Leigh MacMillan
(Adobe Stock)
August 29, 2024

Study finds human milk component may protect adult intestinal health

The research may lead to new treatments for diseases such as inflammatory bowel disease and mucositis, a severe complication of chemotherapy.

By Bill Snyder
July 25, 2024

New study to explore infection response in diabetes

With a $3 million research grant, Henrique Serezani will investigate how altered metabolism in diabetes affects inflammation and sepsis.
By Paul Govern
June 21, 2024

Salmonella bacteria ‘steal’ nutrients from gut’s resident microbes

The discovery could point to novel strategies for treating food poisoning and other types of gastroenteritis.
By Leigh MacMillan
April 9, 2024

Heart disease, depression linked by inflammation: study

Coronary artery disease and major depression may be genetically linked via inflammatory pathways to an increased risk for cardiomyopathy, a degenerative heart muscle disease, researchers at Vanderbilt University Medical Center and Massachusetts General Hospital have found.
By Bill Snyder
March 7, 2024

Blood mutations increase risk for acute kidney injury: study

A U.S.-Canadian research collaboration led by Vanderbilt University Medical Center has identified common, age-associated changes in the blood as a risk factor for acute kidney injury, which occurs in more than 1 in 5 hospitalized adults worldwide.
By Bill Snyder
March 28, 2023

Inflammation implicated in exfoliation syndrome

Computational genetics tools have implicated inflammatory pathways in exfoliation syndrome, the most common cause of secondary glaucoma, which can result in blindness.
By Leigh MacMillan
January 6, 2023

MicroRNAs linked to lipid damage

VUMC researchers have linked microRNAs with systemic lipid peroxidation, a discovery that could point to new therapeutic targets for a variety of diseases.
By Sarah E. Glass
November 17, 2022

A marker for mortality

A urine biomarker of inflammation was associated with increased mortality and multiple lifestyle factors, suggesting that modifications could help reduce premature mortality.
By Sarah E. Glass
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