Journal of Virology

March 9, 2023

Study finds RSV may evade vaccines via rapid mutation

A Vanderbilt study concluded that RSV’s ability to mutate rapidly to escape detection by the body’s immune system makes it more challenging to design and develop vaccines that can stop it from spreading.

By Bill Snyder
February 2, 2023

COVID-19 battle begins in the nose

A high upper airway concentration of the virus that causes COVID-19 was associated with changes in gene expression that could impact disease progression, Vanderbilt researchers discovered.

By Sarah E. Glass
October 6, 2020

Early steps in reovirus replication

Conformational change in a reovirus surface protein modulate the virus’s attachment to host cells, Vanderbilt researchers have found.

By Leigh MacMillan
May 23, 2018

Evolution of a deadly virus

Genomic sequences have revealed that Florida is a major source of a mosquito-borne virus that causes disease in horses and humans.

By Leigh MacMillan
September 22, 2015

Keep your coat on, virus!

A compound acting on serotonin receptors delays a critical step during reovirus cell entry, reducing viral infectivity.

By Sanjay Mishra
February 24, 2015

Contributors to coronavirus ‘fitness’

Understanding the role that host membrane modification plays in coronavirus replication is essential for developing novel approaches to block the viruses that cause SARS and MERS.

By Leigh MacMillan
February 10, 2015

Targeting HIV’s “cap”

New findings underscore the attractiveness of the HIV capsid – the structure that encloses the viral genome – as a therapeutic target.
By VUMC News and Communications
July 23, 2014

Natural killer cells don’t clear HMPV

Understanding how the immune system responds to the respiratory virus HMPV is crucial for developing vaccines and anti-viral treatments.
By Leigh MacMillan
May 27, 2014

Respiratory virus vaccine candidate

Virus-like particles containing a protein from human metapneumovirus are a promising vaccine candidate for this respiratory virus.
By Leigh MacMillan
April 28, 2014

Target cell entry to halt Chikungunya virus

Understanding how chikungunya virus binds to and enters cells offers a new target for antiviral medications.
By Leigh MacMillan
October 31, 2012

Protein’s length, flexibility key to infection

The structural architecture of the reovirus attachment protein is required for efficient reovirus infection of host cells.
By Leigh MacMillan
September 25, 2012

Cell entry ports for cold virus

The respiratory virus HMPV uses its fusion (F) protein – which interacts with cellular receptors called integrins – to bind to and enter target cells.
By Leigh MacMillan