Journal of Virology Archives
Study finds RSV may evade vaccines via rapid mutation
Mar. 9, 2023—A Vanderbilt study concluded that RSV’s ability to mutate rapidly to escape detection by the body’s immune system makes it more challenging to design and develop vaccines that can stop it from spreading.
COVID-19 battle begins in the nose
Feb. 2, 2023—A high upper airway concentration of the virus that causes COVID-19 was associated with changes in gene expression that could impact disease progression, Vanderbilt researchers discovered.
Early steps in reovirus replication
Oct. 6, 2020—Conformational change in a reovirus surface protein modulate the virus’s attachment to host cells, Vanderbilt researchers have found.
Evolution of a deadly virus
May. 23, 2018—Genomic sequences have revealed that Florida is a major source of a mosquito-borne virus that causes disease in horses and humans.
Keep your coat on, virus!
Sep. 22, 2015—A compound acting on serotonin receptors delays a critical step during reovirus cell entry, reducing viral infectivity.
Contributors to coronavirus ‘fitness’
Feb. 24, 2015—Understanding the role that host membrane modification plays in coronavirus replication is essential for developing novel approaches to block the viruses that cause SARS and MERS.
Targeting HIV’s “cap”
Feb. 10, 2015—New findings underscore the attractiveness of the HIV capsid – the structure that encloses the viral genome – as a therapeutic target.
Natural killer cells don’t clear HMPV
Jul. 23, 2014—Understanding how the immune system responds to the respiratory virus HMPV is crucial for developing vaccines and anti-viral treatments.
Respiratory virus vaccine candidate
May. 27, 2014—Virus-like particles containing a protein from human metapneumovirus are a promising vaccine candidate for this respiratory virus.
Target cell entry to halt Chikungunya virus
Apr. 28, 2014—Understanding how chikungunya virus binds to and enters cells offers a new target for antiviral medications.
Protein’s length, flexibility key to infection
Oct. 31, 2012—The structural architecture of the reovirus attachment protein is required for efficient reovirus infection of host cells.
Cell entry ports for cold virus
Sep. 25, 2012—The respiratory virus HMPV uses its fusion (F) protein – which interacts with cellular receptors called integrins – to bind to and enter target cells.
