Molecular Cell (journal)

Madison Adolph, PhD, left, David Cortez, PhD, and Archana Krishnamoorthy are studying fundamental processes involved in DNA replication.
July 22, 2021

Researchers discover that protein switches functions to regulate DNA replication

Vanderbilt biochemists have discovered what the DNA damage response protein RADX does — and how it does it.

By Leigh MacMillan
February 4, 2021

Gene network for leukemia factor

A new method speeds the analysis of factors that control gene expression from days to minutes, allowing researchers to uncover new targets for cancer treatment.

By Leigh MacMillan
May 7, 2020

New method captures early viral-host protein interactions

Researchers have developed a method to identify the primary interactions between incoming viral RNA genomes and host proteins.

By Bill Snyder
February 6, 2020

New tool probes gene regulation

Vanderbilt biochemists got unexpected results when they used their new approach to explore the role of DNA methylation in gene regulation.

By Leigh MacMillan
July 20, 2017

Study identifies protein’s role in chemotherapy resistance

Researchers at Vanderbilt University Medical Center (VUMC) have discovered a protein that may lead to a new way to prevent resistance and improve outcomes for patients whose cancers have mutations in the tumor suppressor gene BRCA2.

By Bill Snyder
DNA sequence visualization
November 12, 2015

Study helps clarify components of DNA ‘copy machine’

Vanderbilt investigators have generated a “parts list” for the molecular machinery that duplicates DNA each time a cell divides. The research has implications for cancer therapies that target components of this machinery.

By Leigh MacMillan
July 16, 2015

Study reveals how protein helps cells tolerate DNA damage

Vanderbilt and Stanford investigators have discovered how a protein that's part of the DNA replication "machinery" helps cells tolerate DNA damage.
By Leigh MacMillan
March 26, 2015

‘Docking stations’ on chromosomes new anti-cancer target

Vanderbilt University researchers have discovered a cleft in a chromosome-binding protein that may hold the key to stopping most cancers in their tracks.
By Bill Snyder