Nature Communications (journal)

From left, Huan Tao, MD, PhD, Sean Davies, PhD, Jiansheng Huang, PhD, and MacRae Linton, MD, led the study that identified a potential new treatment for atherosclerosis.
August 20, 2020

‘Scavenger’ molecule may point to new atherosclerosis treatment

A small-molecule “scavenger” that reduces inflammation and formation of atherosclerotic plaque in blood vessels in mice potentially could lead to a new approach for treating atherosclerosis in humans, according to researchers at Vanderbilt University Medical Center.

By Bill Snyder
July 23, 2020

Cellular antiviral defenses

A cellular RNA quality control mechanism was known to restrict replication of RNA viruses. Vanderbilt researchers have discovered it is also antiviral against DNA viruses.

By Leigh MacMillan
July 9, 2020

Recurrent UTIs linked to hidden reservoir

Bacterial invasion of vaginal cells sets up a protective niche and a reservoir for recurrent urinary tract infections, Vanderbilt researchers demonstrated.

By Sarah E. Glass
March 23, 2020

Study reveals an inherited origin of prostate cancer in families

Vanderbilt researchers have identified haplotypes, ancestral fragments of DNA, that are associated with hereditary prostate cancer (HPC) in a first-of-its-kind genomic study made possible by the study of prostate cancer patients with family histories of the disease.

By Tom Wilemon
x-ray of stomach
January 16, 2020

VUMC study sheds light on gastric cancer development

VUMC researchers have created the world’s first laboratory model of precancerous changes in the lining of the stomach, a scientific tour de force that is helping to unlock the mysteries of gastric cancer development.

By Bill Snyder
Adriana Hung, MD, MPH, talks with patient Sylvester Norman, who is participating in the VA Department’s Million Veteran Program.
September 25, 2019

Study shines light on architecture of kidney disease

A study of 280,000 U.S. veterans, including 56,000 African Americans, has identified in greater detail than ever before the genetic architecture of kidney function and chronic kidney disease (CKD), according to researchers at Vanderbilt University Medical Center and their colleagues.

By Bill Snyder
August 8, 2019

Cellular engines of wound repair have distinct roles

Vanderbilt investigators have discovered that, in contrast to prevailing dogma, fibroblasts are not all alike; instead, they have distinctive functions following tissue injury.
By Leigh MacMillan
May 9, 2019

Rehab technique may boost supply of donor lungs

A new regeneration technique could potentionally add to a limited supply of donor organs for an increasing population with end-stage lung disease.
By Matt Batcheldor
May 3, 2019

Researchers putting the brakes on lethal childhood cancer

Malignant rhabdoid tumor (MRT) is one of the most aggressive and lethal childhood cancers. Although rare — about 20 to 25 new cases are diagnosed annually in the United States — there is no standard effective treatment for the disease, which is driven by loss of an anti-cancer protein called SNF5. The chances are very small that a child will survive a year after MRT diagnosis.
By Bill Snyder
March 14, 2019

Exploring the brain’s white matter

New comprehensive functional MRI measurements point to the need to update models for assessing brain white matter activity and physiology.
By Leigh MacMillan
December 13, 2018

The exocyst dynamo

New methods have revealed details of vesicle trafficking in cells and are applicable to any protein complexes, potentially revolutionizing our understanding of cell dynamics.
By Bill Snyder
December 13, 2018

RNA processing and antiviral immunity

John Karijolich and colleagues have discovered a link between cellular RNA processing and the innate cellular immune response to viral pathogens.
By Leigh MacMillan
October 11, 2018

Team’s study reveals hidden lives of medical biomarkers

What do medical biomarkers do on evenings and weekends, when they might be considered off the clock?
By Paul Govern
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