Vanderbilt University researchers have uncovered a surprising finding that could lead to the development of new, more effective therapies for schizophrenia, which affects more than 2 million Americans.

There is growing evidence that disorders such as autism and schizophrenia involve deficits in what is called “multi-sensory processing,” the ability of the brain to properly integrate information coming in through the eyes, ears and other senses.

Vanderbilt University is partnering with the William K. Warren Foundation of Tulsa, Oklahoma, on research aimed at improving the treatment of schizophrenia and other forms of serious mental illness.

Catatonia, a syndrome characterized by muscular rigidity and a trance-like mental stupor, can at times manifest with great excitement and confusion. And while it is often associated with schizophrenia, it can present in patients with either medical or psychiatric conditions. For this reason, the condition has often confused clinicians.

Although heteromeric dopamine receptors composed of both D1 and D2 subunits have been proposed to play a role in depression and schizophrenia, recent studies suggest these heteromers do not exist.

A “transformational” $6.4 million gift from Dallas couple Donald Test Jr., and his wife, Charlotte, who have a very personal connection to the devastating disease of schizophrenia, is supporting Vanderbilt Department of Psychiatry research and treatment into schizophrenia and related disorders.

Schizophrenia and bipolar disorder share common genetic underpinnings. Vanderbilt researchers combined high-resolution gene expression studies with gene association data to reveal signaling pathways linked to schizophrenia and bipolar disorder.