Science Signaling (journal) Archive — Page 1 of 1

The rod-shaped pathogen C. diff must overcome a variety of threats to survive and grow in the gut. (illustration by Adobe Stock)
September 9, 2026

C. diff coordinates threat response to survive in gut

It’s critical to understand how C. diff adapts to environmental stressors in the gut in order to identify novel antimicrobial targets.

Brooke Emerling, PhD, and Raymond Blind, PhD (seated, in foreground) at a 2023 scientific symposium they organized. Standing next to Blind is Hua Ya, PhD, from the City of Hope Comprehensive Cancer Center. Behind him in the light blue shirt is Emilio Hirsch, PhD, from the University of Torino, Italy.
June 7, 2024

Discovery raises hopes for new cancer therapy

The study connected the Hippo signaling pathway to phosphoinositides, a particular type of lipid, or fat molecule, which regulates cell functions that are critical in cancer, obesity and diabetes.

3D medical illustration of a translucent human torso showing the liver highlighted in bright orange and red beneath the rib cage.
June 22, 2023

Pathways to a healthy liver

Hepatic stellate cells maintain liver mass and function; the signaling factors they use could be exploited therapeutically to promote liver regeneration and inhibit cancerous proliferation, Vanderbilt researchers suggest.

Illustration of two purple neuron endings facing each other across a synaptic gap, with glowing orange-yellow neurotransmitter particles between them.
March 7, 2019

Vanderbilt scientists report new modeling of brain signaling

The release of neurotransmitters and hormones in the body is tightly controlled by complex protein machinery embedded in cell membranes.

3d rendering white blood cells with red blood cells
May 9, 2018

Putting the brakes on sepsis

An enzyme called PTEN reduces inflammatory signaling and mortality in sepsis, suggesting it may be a good therapeutic target for this life-threatening complication of infection.

Illustration of overlapping purple spherical cells, each with a prominent blue spherical nucleus, against a black background.
September 28, 2017

Cellular calcium handling in diabetes

Potassium channels in a cellular organelle regulate calcium flux and appear to play a critical role in pancreatic beta cell health.