Serious pneumococcal infections increase the risk of heart attack
Mar. 2, 2023—A Vanderbilt study found that patients with serious pneumococcal infections, including pneumonia and sepsis, are at a substantially increased risk of heart attack after the onset of infection.
Study of two sepsis interventions finds identical outcomes
Feb. 2, 2023—Vanderbilt University Medical Center had a leading role in a large national study designed to compare two early interventions in the treatment of patients with sepsis, the body’s severe response to an uncontrolled infection.
Vascular dysfunction during sepsis
Oct. 25, 2022—Regulation of the enzyme Sirtuin 1 in blood vessel endothelial cells may drive altered metabolism and vascular dysfunction during sepsis, Vanderbilt researchers have discovered.
Zinc uptake by a deadly pathogen
Jan. 13, 2020—The increasingly antibiotic-resistant bacterium Acinetobacter baumannii requires zinc to cause infection, and Vanderbilt researchers have identified the zinc uptake system it uses.
New test assists physicians with quicker treatment decisions for sepsis
Oct. 3, 2019—Rapid blood culture diagnostics for patients with bacterial bloodstream infections delivered final results in 12 hours versus the two to three days required for conventional testing.
Putting the brakes on sepsis
May. 9, 2018—An enzyme called PTEN reduces inflammatory signaling and mortality in sepsis, suggesting it may be a good therapeutic target for this life-threatening complication of infection.
Sepsis trial ranked No. 1 on critical care website
Feb. 15, 2018—A clinical trial of an intervention for sepsis in patients in Zambia, led by Vanderbilt investigators, topped the list of 2017 trials featured by the website The Bottom Line.
VU scientists report a way to calm the sepsis “storm”
Jun. 22, 2017—Researchers at Vanderbilt University Medical Center (VUMC) have found a way to calm the “genomic storm” that triggers the often-lethal consequences of sepsis.
Pathology of septic shock
Feb. 8, 2017—The signaling molecule IL-15 promotes septic shock, a life-threatening condition involving organ injury caused by infection.
VUMC researchers seek to crack the code of neonatal sepsis
Jun. 2, 2016—Sepsis, an exaggerated and overwhelming inflammatory response to infection, is a major worldwide killer of babies in the first four weeks of life (neonatal period).
Immune tolerance in endothelial cells
Jan. 7, 2016—Inducing “tolerance” to bacterial toxins in the endothelial cells that line blood vessels may offer a new approach for preventing the negative consequences of sepsis.
Antibiotics, fetal vessel defect linked
Oct. 15, 2014—Certain antibiotics increase the risk of a congenital heart disorder called patency of the ductus arteriosis.