sepsis

December 7, 2023

How to get the biggest “bang” for the research “buck”

Vanderbilt researchers are developing new methods to maximize what can be learned from clinical trials and cohort studies, while maintaining their rigor and reproducibility.

By Bill Snyder
The team studying how to control sepsis in the lungs and kidneys includes, from left, Huan Qiao, MD, PhD Jacek Hawiger, MD, PhD, Jozef Zienkiewicz, PhD, and Yan Liu, MD, MS. (photo by Erin O. Smith)
August 21, 2023

Study reveals genomic code for sepsis in the lungs and kidneys

Researchers at Vanderbilt University Medical Center and the Nashville Veterans Affairs Medical Center have “cracked” the genomic code for sepsis in the lungs and kidneys.

By Bill Snyder
June 29, 2023

Persistent inflammatory state found in half of pediatric sepsis deaths: study

New research shows that about half of pediatric patients who died of sepsis over the past 20 years at Vanderbilt University Medical Center had evidence of an inflammatory state called persistent inflammation, immunosuppression and catabolism syndrome.

By Leigh MacMillan
From left, Frank Harrell Jr., PhD, Paul Harris, PhD, Wesley Self, MD, James Chappell, MD, PhD, Gordon Bernard, MD, Jana Shirey-Rice, PhD, and Jillian Rhoads, PhD, play key roles in a national effort to advance the understanding and treatment of acute respiratory distress syndrome, pneumonia and sepsis.
May 4, 2023

VUMC to coordinate national effort to reduce ARDS, pneumonia, sepsis

Vanderbilt University Medical Center has received a $31.6 million federal grant to lead a national effort to better understand acute respiratory distress syndrome, pneumonia and sepsis.

By Bill Snyder
Andrew Wiese, MPH, PhD, left, Carlos Grijalva, MD, MPH, and colleagues found that the risk of a heart attack diagnosis was highest in the first week after onset of pneumococcal infection.
March 2, 2023

Serious pneumococcal infections increase the risk of heart attack

A Vanderbilt study found that patients with serious pneumococcal infections, including pneumonia and sepsis, are at a substantially increased risk of heart attack after the onset of infection.

By Jake Lowary
Wesley Self, MD, MPH
February 2, 2023

Study of two sepsis interventions finds identical outcomes

Vanderbilt University Medical Center had a leading role in a large national study designed to compare two early interventions in the treatment of patients with sepsis, the body’s severe response to an uncontrolled infection.

By Nancy Humphrey
October 25, 2022

Vascular dysfunction during sepsis

Regulation of the enzyme Sirtuin 1 in blood vessel endothelial cells may drive altered metabolism and vascular dysfunction during sepsis, Vanderbilt researchers have discovered.
By Leigh MacMillan
January 13, 2020

Zinc uptake by a deadly pathogen

The increasingly antibiotic-resistant bacterium Acinetobacter baumannii requires zinc to cause infection, and Vanderbilt researchers have identified the zinc uptake system it uses.
By Leigh MacMillan
October 3, 2019

New test assists physicians with quicker treatment decisions for sepsis

Rapid blood culture diagnostics for patients with bacterial bloodstream infections delivered final results in 12 hours versus the two to three days required for conventional testing.
By Jessica Pasley
May 9, 2018

Putting the brakes on sepsis

An enzyme called PTEN reduces inflammatory signaling and mortality in sepsis, suggesting it may be a good therapeutic target for this life-threatening complication of infection.
By Leigh MacMillan
February 15, 2018

Sepsis trial ranked No. 1 on critical care website

A clinical trial of an intervention for sepsis in patients in Zambia, led by Vanderbilt investigators, topped the list of 2017 trials featured by the website The Bottom Line.
By Leigh MacMillan
June 22, 2017

VU scientists report a way to calm the sepsis “storm”

Researchers at Vanderbilt University Medical Center (VUMC) have found a way to calm the “genomic storm” that triggers the often-lethal consequences of sepsis.
By Bill Snyder
February 8, 2017

Pathology of septic shock

The signaling molecule IL-15 promotes septic shock, a life-threatening condition involving organ injury caused by infection.
By Leigh MacMillan
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