sepsis Archives

The team studying how to control sepsis in the lungs and kidneys includes, from left, Huan Qiao, MD, PhD Jacek Hawiger, MD, PhD, Jozef Zienkiewicz, PhD, and Yan Liu, MD, MS. (photo by Erin O. Smith)

Study reveals genomic code for sepsis in the lungs and kidneys

Aug. 21, 2023—Researchers at Vanderbilt University Medical Center and the Nashville Veterans Affairs Medical Center have “cracked” the genomic code for sepsis in the lungs and kidneys.

Persistent inflammatory state found in half of pediatric sepsis deaths: study

Jun. 29, 2023—New research shows that about half of pediatric patients who died of sepsis over the past 20 years at Vanderbilt University Medical Center had evidence of an inflammatory state called persistent inflammation, immunosuppression and catabolism syndrome.

From left, Frank Harrell Jr., PhD, Paul Harris, PhD, Wesley Self, MD, James Chappell, MD, PhD, Gordon Bernard, MD, Jana Shirey-Rice, PhD, and Jillian Rhoads, PhD, play key roles in a national effort to advance the understanding and treatment of acute respiratory distress syndrome, pneumonia and sepsis.

VUMC to coordinate national effort to reduce ARDS, pneumonia, sepsis

May. 4, 2023—Vanderbilt University Medical Center has received a $31.6 million federal grant to lead a national effort to better understand acute respiratory distress syndrome, pneumonia and sepsis.

Andrew Wiese, MPH, PhD, left, Carlos Grijalva, MD, MPH, and colleagues found that the risk of a heart attack diagnosis was highest in the first week after onset of pneumococcal infection.

Serious pneumococcal infections increase the risk of heart attack

Mar. 2, 2023—A Vanderbilt study found that patients with serious pneumococcal infections, including pneumonia and sepsis, are at a substantially increased risk of heart attack after the onset of infection.

Study of two sepsis interventions finds identical outcomes

Feb. 2, 2023—Vanderbilt University Medical Center had a leading role in a large national study designed to compare two early interventions in the treatment of patients with sepsis, the body’s severe response to an uncontrolled infection.

Vascular dysfunction during sepsis

Oct. 25, 2022—Regulation of the enzyme Sirtuin 1 in blood vessel endothelial cells may drive altered metabolism and vascular dysfunction during sepsis, Vanderbilt researchers have discovered.

Zinc uptake by a deadly pathogen

Jan. 13, 2020—The increasingly antibiotic-resistant bacterium Acinetobacter baumannii requires zinc to cause infection, and Vanderbilt researchers have identified the zinc uptake system it uses.

New test assists physicians with quicker treatment decisions for sepsis

Oct. 3, 2019—Rapid blood culture diagnostics for patients with bacterial bloodstream infections delivered final results in 12 hours versus the two to three days required for conventional testing.

3d rendering white blood cells with red blood cells

Putting the brakes on sepsis

May. 9, 2018—An enzyme called PTEN reduces inflammatory signaling and mortality in sepsis, suggesting it may be a good therapeutic target for this life-threatening complication of infection.

Sepsis trial ranked No. 1 on critical care website

Feb. 15, 2018—A clinical trial of an intervention for sepsis in patients in Zambia, led by Vanderbilt investigators, topped the list of 2017 trials featured by the website The Bottom Line.

storming night with many bolts of lightning

VU scientists report a way to calm the sepsis “storm”

Jun. 22, 2017—Researchers at Vanderbilt University Medical Center (VUMC) have found a way to calm the “genomic storm” that triggers the often-lethal consequences of sepsis.