Research

December 18, 2023

Study examines social factors and cardiovascular disease risk

Eight social factors were among the top 15 markers of cardiovascular disease risk and could help guide community prevention efforts, according to a new study using machine learning algorithms.

By Paul Govern
Authors on the study included, from left, Jennifer Pietenpol, PhD, Melinda Sanders, MD, Brian Lehmann, PhD, Vandana Abramson, MD, and Yu Shyr, PhD. (photo by Donn Jones)
December 15, 2023

Clinical trial shows efficacy for atezolizumab combined with carboplatin

By Tom Wilemon
Ken Lau, PhD, left, and Bob Coffey, MD, have made several important discoveries about colorectal cancer that are aiding the search for new, more effective therapies. (photo by Erin O. Smith)
December 11, 2023

Colorectal cancer ‘cartography’ reveals an avenue to improved immunotherapy

Vanderbilt University Medical Center researchers have discovered why most colorectal tumors escape detection and destruction by the body’s immune system.

By Bill Snyder
Bob Coffey, MD
December 8, 2023

Vanderbilt research presented at Cancer Moonshot meet

Vanderbilt Colorectal cancer expert Bob Coffey, MD, was recently invited to present his research to representatives of President Joe Biden’s reignited Cancer Moonshot initiative.

By Bill Snyder
Mariana Byndloss, DVM, PhD, (left), graduate student Catherine Shelton, and their colleagues discovered that beneficial bacteria in the small intestines produce a compound that protects against obesity. (photo by Erin O. Smith)
December 8, 2023

Gut microbiota metabolite protects against obesity: study

Vanderbilt researchers have discovered that beneficial bacteria in the small intestines produce a compound that protects against obesity.

By Leigh MacMillan
December 8, 2023

You missed a few: a better way to count health care-associated influenza cases

The traditional definition of health care-associated influenza leads to gross undercounting, a Vanderbilt study suggests.

By Paul Govern
December 7, 2023

How to get the biggest “bang” for the research “buck”

Vanderbilt researchers are developing new methods to maximize what can be learned from clinical trials and cohort studies, while maintaining their rigor and reproducibility.
By Bill Snyder
December 6, 2023

Pasteurization reduces bioactive component of breast milk

Pasteurization of breast milk affects the concentration of osteopontin, a bioactive protein with roles in intestinal, immunological and brain development — suggesting that osteopontin supplementation should be considered when donor milk is provided to preterm infants.
By Leigh MacMillan
December 5, 2023

Role of immunity in kidney injury hints at a potential therapy: study

Targeting the cytokine IL-22 could be a new therapeutic approach to prevent kidney injury caused by drugs or toxins, Vanderbilt researchers have discovered.
By Bill Snyder
December 4, 2023

Study links gene network and pancreatic beta cell defects to Type 2 diabetes

A comprehensive study that integrates multiple analytic approaches has linked a regulatory gene network and functional defects in insulin-producing pancreatic beta cells to Type 2 diabetes.
By Leigh MacMillan and Jill Clendening
November 29, 2023

Nonprofits support quest to cure childhood epilepsy

Monica Joanna Elnekaveh was doing everything she could to learn what was causing her 18-month-old daughter’s developmental issues. Her relentless quest to find answers eventually led her to Vanderbilt investigative neurologist Jing-Qiong (Katty) Kang, MD, PhD.
By Bill Snyder
November 21, 2023

Commensal gut bacterium protects from severe intestinal infection

The commensal bacterium Turicibacter sanguinis could be used to protect against severe intestinal infections, Vanderbilt researchers discovered.
By Leigh MacMillan
November 21, 2023

VUMC scientists discover key step to kidney fibrosis

Researchers at Vanderbilt University Medical Center for the first time have shown that activation of the epidermal growth factor receptor (EGFR) is essential for the development of kidney fibrosis, tissue scarring following injury that can lead to kidney failure.
By Bill Snyder
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