Research

October 29, 2020

New tool rapidly identifies health records for studies

Electronic health records (EHR) are increasingly a resource for biomedical discovery, and automated searches for records that reflect a phenotype of interest, typically a disease, are a common starting point.

By Paul Govern
October 29, 2020

Histamine circuits in brain reward center

Histamine — commonly associated with allergies — also has a signaling role in the brain’s reward center and may offer a novel target for treating addiction.

By Leigh MacMillan
October 29, 2020

New markers of colorectal cancer risk

Vanderbilt epidemiologists identified new markers for colorectal cancer risk and characterized a previously unidentified tumor suppressor that regulates overall tumor volume in vivo.

By Sarah E. Glass
October 26, 2020

COVID treatment studied by VUMC gains FDA approval

Researchers at Vanderbilt University Medical Center played a key role in the development of remdesivir, the first drug approved by the U.S. Food and Drug Administration for the treatment of COVID-19.

By Bill Snyder
October 22, 2020

New tool to probe genetic mechanisms of disease

Vanderbilt Genetics Institute investigators have added a new method to the computational genetics toolbox. Their approach, described in the journal Nature Genetics, integrates vast genomics datasets to predict gene expression and facilitate discovery of genetic mechanisms underlying human diseases.

By Leigh MacMillan
October 22, 2020

Lindsley to direct Center for Neuroscience Drug Discovery

Craig Lindsley, PhD, the William K. Warren Jr. Chair in Medicine and University Professor of Pharmacology, Biochemistry and Chemistry, will become director of Vanderbilt University’s Warren Center for Neuroscience Drug Discovery (WCNDD), effective Dec. 1. Lindsley assumes the director position from Jeffrey Conn, PhD, Lee. E. Limbird Chair in Pharmacology and professor of Pharmacology.

By VUMC News and Communications
October 20, 2020

Preserving gut mucus architecture

A new method that keeps microbes and gut cells together will be useful for studies of complex host-microbe interactions and for analysis of clinical specimens.
By Leigh MacMillan
October 19, 2020

Depression and the brain-age gap

Older depressed adults show accelerated brain aging, according to a new study from Vanderbilt researchers, who suggest that the effects of depression may speed the decline in cognitive functions in older individuals.
By Sarah E. Glass
October 15, 2020

Possible COVID-19 “decoy”

It might be possible to use vesicles carrying the receptor for SARS-CoV-2, the virus that causes COVID-19, to bind the virus and prevent infection.
By Bill Snyder
October 15, 2020

Factor involved in stomach injury response identified

Researchers at Vanderbilt University Medical Center have identified a key factor that coordinates the body’s repair response to severe injury in the stomach caused, most commonly, by infection by the bacterium Helicobacter pylori.
By Bill Snyder
October 15, 2020

Brain blood vessel response to hypoxia

The brain’s response to low oxygen — growth and remodeling of blood vessels — involves certain cell types and molecular pathways, Vanderbilt researchers have discovered.
By Leigh MacMillan
October 13, 2020

COVID-19 long-acting antibodies discovered by Vanderbilt University Medical Center move to phase 3 clinical trials

AstraZeneca is advancing into phase 3 clinical trials with an investigational COVID-19 therapy of two long-acting antibodies discovered by Vanderbilt University Medical Center and optimized by AstraZeneca.
By Bill Snyder
October 8, 2020

Computer-based study reveals impact of race on health

A computer-based method developed at Vanderbilt University Medical Center that scans electronic medical records (EMRs) for genetic contributors to disease has been used for the first time to reveal the impact of race on health.
By Bill Snyder
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