Physical exercise alone generally fails to produce meaningful weight loss in obese individuals, and reduced non-exercise activity has been suggested to explain this observation.
Daniel Lark, PhD, used the unique expertise and tools in the Vanderbilt Mouse Metabolic Phenotyping Center to explore how interactions between exercise (voluntary wheel running) and non-exercise activity (“off-wheel” activity) affect energy balance in mice.
The investigators continuously monitored mouse behavior, energy intake and energy expenditure with locked running wheels (no exercise) for four days, followed by unlocked running wheels for nine days.
The researchers reported in the journal Diabetes that when running wheels were unlocked, mice engaged in voluntary exercise, which increased their energy expenditure and resulted in a negative energy balance. However, wheel running caused mice to decrease their off-wheel activity, such as roaming behavior. This reduction in non-exercise activity blunted the negative energy balance.
The study is the first to report an independent contribution of non-exercise physical activity to energy expenditure and energy balance in mice. By doing so, the study provides a model to further study mechanisms that regulate body weight.
Other Vanderbilt faculty instrumental in this work were Louise Lantier, PhD, and David H. Wasserman, PhD. This research was supported by grants from the National Institutes of Health (DK076169, DK054902, DK059637) and the American Heart Association.
Send suggestions for articles to highlight in Aliquots and any other feedback about the column to aliquots@vanderbilt.edu
