Paul Govern

Treatment resistance of mental disorders studied

With the aid of a four-year, $3.4 million grant from the National Institute of Mental Health, researchers at Vanderbilt University Medical Center and Massachusetts General Hospital (MGH) will apply new techniques to investigate treatment resistance of two devastating mental disorders — major depressive disorder, which befalls 15 percent of people at some point in their lives, and schizophrenia, which affects approximately 1 percent.

Skin diseases study uses crowdsourcing to gather data

In 1906, English statistician Francis Galton happened to visit a livestock fair where fairgoers were invited to guess the dressed weight of an ox scheduled for imminent slaughter. Some 800 attendees took part and afterwards Galton got hold of the contest data.

Lisa Bastarache, MS, Josh Denny, MD, MS, and colleagues are helping researchers study associations among de-identified genotype data and electronic health records data. (photo by John Russell)

PheWAS Core helps researchers make sense of electronic health record data

Some biomedical researchers may be unsure about routine electronic health record (EHR) data and how useful it ultimately may prove for drawing meaningful, actionable associations that warrant changes to clinical practice and lead to improved clinical outcomes.

Study explores genetic risk for suicide attempt

Using data from the UK Biobank and Vanderbilt’s BioVU, a new study in the journal Molecular Psychiatry finds that approximately 4 percent of suicide attempt risk is captured by genotype data.

Study finds patient messages help predict medication adherence

Around two-thirds of patients treated for breast cancer will have had hormone-sensitive tumors and, after their initial treatment, will be advised to undergo hormone therapy for five to 10 years to prevent recurrence.

Study tracks repercussions from reduced pre-op testing

When clinical teams at Vanderbilt University Medical Center dramatically reduced several types of preoperative testing for elective surgery patients, there were no repercussions for these patients in terms of case cancellation rates, average length of stay in the hospital or rates of readmission to VUMC.

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