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Author: Leigh MacMillan

Magnesium deficiency and blood pressure

Jun. 26, 2023—Dietary magnesium depletion in a mouse model activated inflammatory pathways and molecules that promote hypertension, suggesting that increased magnesium consumption may be beneficial for reducing the prevalence of hypertension.

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Mosaicism and genetic disease

Jun. 22, 2023—Genetic mosaicism — when the body’s cells do not all have the same genetic makeup — could generate variants previously thought to be spontaneous in genetic disease, and detecting parental mosaicism could clarify recurrence risk for future children.

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Targeting calcium handling in A-fib

Jun. 8, 2023—The drug ent-verticilide reduced A-fib incidence and duration in an animal model, suggesting it may be a viable therapeutic option.

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Byndloss selected for Burroughs Wellcome Fund infectious disease award

Jun. 7, 2023—Vanderbilt's Mariana Byndloss, DVM, PhD, is one of eight Burroughs Wellcome Fund 2023 Investigators in the Pathogenesis of Infectious Disease.

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Neurofluid flow and Alzheimer’s disease

May. 22, 2023—Vanderbilt researchers used novel MRI methods to noninvasively quantify measures of neurofluid circulation and found that hypertrophy of a site of cerebrospinal fluid egress may be related to amyloid-beta retention in Alzheimer’s disease.

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A critical skin enzyme

May. 18, 2023—Detailed studies of the enzymatic properties of PNPLA1 support the requirement for this protein in skin barrier formation.

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Neural networks probe proteins

May. 9, 2023—A machine learning method based on neural networks outperformed a mutational scanning model at identifying disease-causing mutations in an Alzheimer’s disease protein, suggesting the method could be useful for facilitating therapeutic design.

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Diabetes drugs associated with fewer adverse cardiac events in older veterans: study

May. 8, 2023—Vanderbilt research finds that GLP1 receptor agonists — a class of diabetes medications — are associated with fewer major adverse cardiovascular events than another type of diabetes drug (DPP4 inhibitors) in older veterans with no prior heart disease.

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Improved imaging for kidney disease

May. 8, 2023—Vanderbilt researchers identified optimal MRI parameters for estimating the severity of polycystic kidney disease, a common inherited disorder that can lead to end-stage renal failure.

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Tracking lung macrophages

May. 4, 2023—A new technique will allow researchers to track subsets of immune cells that patrol and defend the lungs, to better understand the roles of these cells during lung inflammation, infection and injury.

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COVID alters respiratory microbiota

Apr. 25, 2023—COVID-19 infection alters the microbes of the upper respiratory tract for at least several weeks, and such disturbances could impact disease severity and be targets for therapeutic interventions.

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Novel drugs have potential for treating tuberculosis

Apr. 24, 2023—Drug-resistant tuberculosis is on the rise, and novel antibacterial drugs called SPTs have potential for treating the deadly lung infection.

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