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Author: Leigh MacMillan

Breast cancer genetics: new insights

Feb. 16, 2023—Largest genetic study of breast cancer to date identifies 222 genetic risk loci, 137 genes and multiple signaling pathways associated with risk, providing important new insights.

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Gut microbiota and lung fibrosis

Feb. 6, 2023—Microorganisms residing in the gut influence the severity of lung fibrosis in mouse models, suggesting that modifying the gut microbiota may offer therapeutic benefit for patients.

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Nutrient absorption disease model

Feb. 2, 2023—Vanderbilt researchers developed a model of a patient-specific mutation to explore the pathology of microvillus inclusion disease, a genetic disorder that causes life-threatening diarrhea.

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Low potassium injures kidney

Jan. 19, 2023—Vanderbilt researchers have discovered that low dietary potassium causes direct kidney injury, suggesting potential new targets for treating chronic kidney disease.

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Study identifies potential new approach for treating lupus

Jan. 13, 2023—A Vanderbilt study found that targeting iron metabolism in immune system cells may offer a new approach for treating systemic lupus erythematosus — the most common form of the chronic autoimmune disease lupus.

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Chan Zuckerberg Initiative grant supports single-cell study of rare inherited disease

Jan. 12, 2023—A multidisciplinary team led by Vanderbilt University Medical Center investigator Alexander Bick, MD, PhD, has been awarded a $2 million, four-year grant to study inflammation at the single-cell level in the rare disease RUNX1-FPD.

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Anti-nausea drug response in children

Jan. 10, 2023—Genetic variation in a metabolic enzyme was not associated with response to the anti-nausea drug odansetron in children, Vanderbilt researchers report.

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Novel lung cancer biomarker

Jan. 9, 2023—Autoantibodies against the p53 tumor suppressor protein may be a novel biomarker for identifying people, especially African Americans, at high risk for lung cancer.

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VUMC researchers upend dogma about vasopressin production

Jan. 5, 2023—Vanderbilt investigators have discovered that vasopressin, which has long been thought to be produced only in the brain, is also produced in the kidney.

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Novel therapeutic target identified for chronic kidney disease

Dec. 15, 2022—Vanderbilt investigators have discovered a molecular mechanism that promotes chronic kidney disease following kidney injury.

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Researchers develop framework for multiancestry genomic studies

Dec. 8, 2022—Vanderbilt researchers have developed a framework for the analysis of multiancestry, large-scale genomic studies across multiple biobanks.

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New radiology order priority options go live in January 2023

Nov. 29, 2022—The radiology order entry system in eStar will be updated to allow providers to choose from four options — based on a patient’s medical needs — when requesting studies for hospitalized and emergency department patients. The update is scheduled to go live on Jan. 11, 2023.

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