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Author: Leigh MacMillan

Nerve cells and cancer progression

Sep. 22, 2022—Immature nerves and neural precursor cells increase in density as a type of premalignant tumor in the pancreas progresses to invasive disease, suggesting that blocking these cells may arrest malignant progression.

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Study suggests new mechanism for lipid transporter

Sep. 15, 2022—A new model suggests that a protein involved in the generation of high-density lipoprotein (HDL) works differently than previously thought.

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Cancer registries and sarcoma research

Sep. 13, 2022—The number of sarcoma research studies that use the two largest U.S. cancer registries is increasing, but over one-third of studies that asked the same research question reported conflicting findings.

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Enhancing innate immunity in the lung

Sep. 12, 2022—Vanderbilt researchers show that a TLR4 agonist improves lung immune response and survival in a mouse model of bacterial pneumonia, supporting the development of this drug to protect against pneumonia in hospitalized patients.

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Study identifies key player in T cell “education”

Sep. 1, 2022—New Vanderbilt research could inform therapeutic strategies for enhancing thymic function when desired — such as during aging, recovery from radiation therapy or chemotherapy, or other conditions that reduce T cell output.

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A new mechanism for lupus

Aug. 30, 2022—Vanderbilt researchers describe a new mechanism for the most common form of lupus and suggest a new treatment approach to this autoimmune disease.

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Blood cancer progression

Aug. 29, 2022—Vanderbilt researchers used single-cell technologies to explore the accumulation of mutations during blood cancer progression, which could help identify strategies for preventing leukemia before it occurs.

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Vanderbilt researchers discover how gut inflammation leads to bone loss

Aug. 25, 2022—Gastrointestinal inflammation, such as occurs in inflammatory bowel disease, triggers the expansion of a population of “bone-eating” cells, leading to bone loss.

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Researchers discover how salt increases blood pressure

Aug. 17, 2022—A Vanderbilt research team has discovered that activation of a certain protein complex involved in the inflammatory response in immune cells contributes to salt-sensitive hypertension.

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Mitochondria and retinal degeneration

Aug. 15, 2022—Vanderbilt researchers have developed a new cellular model for exploring mitochondrial dysfunction in age-related macular degeneration, the leading cause of blindness in people over 65.

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Genotype-specific blood counts

Aug. 11, 2022—Vanderbilt researchers report genotype-specific reference ranges to improve interpretation of laboratory blood results in African Americans with a common gene variant that lowers white blood cell counts.

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Targeted cancer drug during pregnancy

Aug. 2, 2022—The targeted cancer therapy alectinib was safe as a treatment for lung cancer during two pregnancies in a patient with non-small cell lung cancer, according to a case report from Vanderbilt physicians.

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