Leigh MacMillan

September 12, 2023

Discovery lecture features computational cancer biologist Pe’er

Dana Pe’er, PhD, a pioneer in using machine learning approaches to explore cell identities and interactions, will deliver the next Discovery Lecture on Thursday, Sept. 21.

By Leigh MacMillan
Heather Pua, MD, PhD, and Neil Sprenkle, PhD, have discovered a protective role for microRNAs in immune cell macrophages during obesity, potentially opening new therapeutic avenues.
September 5, 2023

MicroRNAs in immune cells help protect against metabolic defects in obesity: study

Vanderbilt researchers have demonstrated that a cluster of microRNAs — small pieces of RNA that regulate gene expression — work in a type of immune cells called macrophages to help protect against metabolic defects in obesity.

By Leigh MacMillan
Mary Philip, MD, PhD, left, and Michael Rudloff, PhD, found that T cells become “exhausted” within hours of encountering a tumor, challenging existing ideas about how T cells become dysfunctional. (photo by Anthony Czelusniak)
August 3, 2023

Study finds hallmarks of T cell exhaustion within hours of tumor exposure

Vanderbilt researchers found that T cells become “exhausted” within hours of encountering a tumor, challenging existing ideas about how T cells become dysfunctional.

By Leigh MacMillan
August 2, 2023

Personalizing treatment for sinus syndrome

Understanding the inflammatory characteristics of subtypes of chronic rhinosinusitis with polyps should assist with selection of effective therapies, Vanderbilt researchers report.

By Leigh MacMillan
July 25, 2023

Signaling pathways in liposarcomas

A broad bioinformatics approach revealed that Hedgehog signaling is upregulated in dedifferentiated liposarcoma, suggesting this pathway may be an early indicator of poor prognosis and a potential therapeutic target.

By Leigh MacMillan
July 13, 2023

Female health care workers more likely to leave profession during pandemic: HERO registry study

Vanderbilt research finds that female health care workers were more likely to leave or intend to leave the profession compared to male health care workers during the COVID-19 pandemic.

By Leigh MacMillan
June 29, 2023

Persistent inflammatory state found in half of pediatric sepsis deaths: study

New research shows that about half of pediatric patients who died of sepsis over the past 20 years at Vanderbilt University Medical Center had evidence of an inflammatory state called persistent inflammation, immunosuppression and catabolism syndrome.
By Leigh MacMillan
June 26, 2023

Magnesium deficiency and blood pressure

Dietary magnesium depletion in a mouse model activated inflammatory pathways and molecules that promote hypertension, suggesting that increased magnesium consumption may be beneficial for reducing the prevalence of hypertension.
By Leigh MacMillan
June 23, 2023

Women band together to renew lactation spaces at VUMC

“Some people consider lactation spaces a human resources benefit; we think of it as a right and an obligation.”
By Leigh MacMillan
June 22, 2023

Mosaicism and genetic disease

Genetic mosaicism — when the body’s cells do not all have the same genetic makeup — could generate variants previously thought to be spontaneous in genetic disease, and detecting parental mosaicism could clarify recurrence risk for future children.
By Leigh MacMillan
June 8, 2023

Targeting calcium handling in A-fib

The drug ent-verticilide reduced A-fib incidence and duration in an animal model, suggesting it may be a viable therapeutic option.
By Leigh MacMillan
May 22, 2023

Neurofluid flow and Alzheimer’s disease

Vanderbilt researchers used novel MRI methods to noninvasively quantify measures of neurofluid circulation and found that hypertrophy of a site of cerebrospinal fluid egress may be related to amyloid-beta retention in Alzheimer’s disease.
By Leigh MacMillan
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