Leigh MacMillan

June 16, 2014

Factor impacts bone toughness

The factor ATF4 has a role in the toughness of bone and its resistance to fracture, suggesting new therapeutic targets.

By Leigh MacMillan
June 13, 2014

How ABC transporters move molecules

New views of how transporters move molecules across cell membranes are key to understanding how these proteins impact tumor cell drug resistance and inherited diseases such as cystic fibrosis.

By Leigh MacMillan
May 29, 2014

Pioneers of Discovery: Investigator taps into artistic side to reveal cells’ secrets

Dylan Burnette, Ph.D., points to one of the many striking photographs on his office walls. It’s a picture of a cell — a microscopic image showing yellow squiggles, bright purple lines and a turquoise oval on a black background, and it looks like abstract art.

By Leigh MacMillan
May 29, 2014

Exploring Wilms tumor race disparity

Unique molecular “fingerprints” could explain the disparity in Wilms tumor incidence and point to novel, race-specific therapeutic targets.

By Leigh MacMillan
May 27, 2014

Respiratory virus vaccine candidate

Virus-like particles containing a protein from human metapneumovirus are a promising vaccine candidate for this respiratory virus.

By Leigh MacMillan
May 23, 2014

Repair protein’s DNA recognition motif

Insights into the workings of DNA damage response proteins such as SMARCAL1 could suggest new ways to improve genome integrity and prevent cancer.

By Leigh MacMillan
May 15, 2014

Biomedical Sciences graduates driven by promise of discovery

Most people probably don’t think much about the chemical compound that flavors curries and gives the Indian spice turmeric its yellow color. For Odaine Gordon, Ph.D., who celebrated his doctoral degree at last week’s Graduate School commencement, this compound — called curcumin — has special significance.
By Leigh MacMillan
May 12, 2014

Normalizing calcium flux to treat atrial fibrillation

A particular anti-arrhythmia drug provides a targeted treatment for certain forms of atrial fibrillation.
By Leigh MacMillan
May 8, 2014

PET probe detects dying tumor cells

A novel PET imaging probe detects tumor cell death in vivo and could be useful for personalizing cancer medicine.
By Leigh MacMillan
April 30, 2014

Potential mechanism for myeloma drug’s variable toxicity

A genetic variant is associated with toxicity of the chemotherapy drug melphalan, and could guide individualized dosing for the medication.
By Leigh MacMillan
April 28, 2014

Target cell entry to halt Chikungunya virus

Understanding how chikungunya virus binds to and enters cells offers a new target for antiviral medications.
By Leigh MacMillan
April 25, 2014

Increased cell permeability may protect from colitis

Having a “leaky” gut may protect against colitis, a paradoxical finding that alters understanding of the role of cell permeability in intestinal homeostasis and immune regulation.
By Leigh MacMillan
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